肿瘤体积作为全喉切除治疗晚期喉癌患者生存预测因素。
Tumor volume as a predictor of survival in advanced laryngeal cancer treated with total laryngectomy.
发表日期：2023 Apr 03
作者：
Krishna S Hanubal, Zhanna Galochkina, Ji-Hyun Lee, Marna A List, Tara C Massini, Dustin Conrad, Brian Hughley, Deepa Danan, Reordan DeJesus, Kathryn Hitchcock, Spencer Nichols, William Mendenhall, Peter T Dziegielewski
来源：
Disease Models & Mechanisms
摘要：
最近的文献显示，T3喉鳞状细胞癌（LSCC）中的肿瘤体积（TV）与放射治疗的反应有关。本研究的目的是评估TV对接受全喉切除术（TL）的患者的生存结果的影响。纳入了在佛罗里达大学于2013年至2020年间接受TL的117例LSCC患者。使用先前经过验证的方法，在术前CT扫描上测量了TV。使用TV开发了关于总生存期（OS）和病例特异性生存期（DSS）、无转移生存期（MFS）和无复发生存期（RFS）的多变量CoxPH模型。平均年龄为61.5岁，其中81.2%为男性。较高的TV与调整后的风险比1.02 (95%CI: 1.01, 1.03)、1.01 (95%CI: 1.00, 1.03)、1.03 (95%CI: 1.01, 1.06) 和1.02 (95%CI: 1.00, 1.03) 相关，这分别影响了OS、MFS、DSS和RFS。TV >7.1 cc具有较差的预后。TV似乎与接受TL治疗的LSCC患者的生存减少有关。©2023 Wiley Periodicals LLC.
Recent literature shows that tumor volume (TV) in T3 laryngeal squamous cell carcinoma (LSCC) is associated with response to radiation therapy. The aim of this study was to evaluate the effect of TV on survival outcomes in patients undergoing total laryngectomy (TL).One hundred and seventeen patients with LSCC undergoing TL between 2013 and 2020 at the University of Florida were included. TV was measured using a previously validated method on preoperative-CT scans. Multivariable CoxPH models for overall survival (OS) and disease-specific survival (DSS), metastasis-free survival (MFS), and recurrence-free survival (RFS) were developed with TV.Mean age was 61.5 years and 81.2% were male. Higher TV was associated with decreased OS, MFS, DSS, and RFS with adjusted hazard ratios 1.02 (95%CI: 1.01, 1.03), 1.01, (95%CI: 1.00, 1.03), 1.03 (95%CI: 1.01, 1.06), and 1.02 (95%CI: 1.00, 1.03) respectively. TV >7.1 cc had worse prognoses.TV appears associated with decreased survival in LSCC treated with TL.© 2023 Wiley Periodicals LLC.