Ferroptosis是一种依赖于铁离子、与凋亡、火凋亡和坏死不同的细胞死亡通路。其主要特点包括由胞内自由二价铁离子介导的Fenton反应、细胞膜脂质过氧化和抑制胞内谷胱甘肽过氧化酶4 (GPX4) 的抗脂质过氧化活性。最近的研究表明，ferroptosis 可以参与多种疾病的病理过程，如缺血再灌注损伤、神经系统疾病和血液疾病。然而，ferroptosis 参与急性白血病的发生和发展的具体机制仍需进一步深入研究。本文综述了ferroptosis的特点及促进或抑制ferroptosis的调控机制。更重要的是，它进一步讨论了ferroptosis在急性白血病中的作用，预测了ferroptosis在急性白血病治疗策略中所带来的变化，为更深入了解ferroptosis在急性白血病中的作用提供了思路。版权所有©2023年中国医师协会，由沃尔特斯·克鲁尔公司根据CC-BY-NC-ND许可证制作。

Ferroptosis is an iron-dependent cell death pathway that is different from apoptosis, pyroptosis, and necrosis. The main characteristics of ferroptosis are the Fenton reaction mediated by intracellular free divalent iron ions, lipid peroxidation of cell membrane lipids, and inhibition of the anti-lipid peroxidation activity of intracellular glutathione peroxidase 4 (GPX4). Recent studies have shown that ferroptosis can be involved in the pathological processes of many disorders, such as ischemia-reperfusion injury, nervous system diseases, and blood diseases. However, the specific mechanisms by which ferroptosis participates in the occurrence and development of acute leukemia still need to be more fully and deeply studied. This article reviews the characteristics of ferroptosis and the regulatory mechanisms promoting or inhibiting ferroptosis. More importantly, it further discusses the role of ferroptosis in acute leukemia and predicts a change in treatment strategy brought about by increased knowledge of the role of ferroptosis in acute leukemia.Copyright © 2023 The Chinese Medical Association, produced by Wolters Kluwer, Inc. under the CC-BY-NC-ND license.