本特别主题论文的目的是回顾美国乳房植入物历史上的关键事件，包括导致FDA暂停使用硅凝胶植入物和随后的批准，乳房植入物相关的大细胞淋巴瘤的出现以及对乳房植入物、自身免疫疾病和全身症状之间关联的持续关注。本文通过审查医学文献概述了我们对BIA-ALCL的当前知识，并提出了有关纹理植入物的症状性和无症状患者的诊断和治疗建议，以及植入物可能与自身免疫和全身症状有关联的科学问题，以便我们能够帮助患者区分神话和现实，并对安置或拆除乳房植入物做出明智的决定。版权所有 ©2023美国整形外科医师协会。

The purpose of this special topic paper is to review the pivotal events in the history of breast implants in the United States, from the events leading to the FDA Moratorium on the use of silicone gel implants and subsequent approval, the emergence of breast implant associated anaplastic large cell lymphoma, and persistent concerns about an association between breast implants, autoimmune disease, and systemic symptoms. This paper reviews the medical literature to outline our current knowledge on BIA-ALCL with recommendations for diagnosis and management of symptomatic and asymptomatic patients with textured implants and the science of potential associations of implants to autoimmune and systemic symptoms so that we can help our patients separate myths from reality and make educated decisions on having breast implants placed or removed.Copyright © 2023 by the American Society of Plastic Surgeons.