中性粒细胞是主要的白细胞，被招募至发炎和感染部位。它们被认为具有促进（促肿瘤）或表现出抗癌性质（抗肿瘤）的双重作用。中性粒细胞根据表型和功能特征进行分类。在癌症生物学中，循环多形核中性粒细胞（cPMN）和肿瘤相关中性粒细胞（TAN）已得到深入研究，但仅限于口腔鳞状细胞癌（OSCC）中的口腔多形核中性粒细胞（oPMNs）。然而，oPMNs 在维持健康的口腔生态系统中至关重要，可以中和微生物。中和过程增强了细胞表面标记物（CD11b、CD63、CD66、CD66b、CD66c 和 CD66e）和炎症细胞因子（TNF-α、IFN-γ、GM-CSF 和 IL-8）的表达，并增加了中性粒细胞的招募。以及炎症一起，报道称 CEACAM1 和化学素也有利于中性粒细胞浸润到癌症部位。这表明 oPMN 可能对 OSCC 的病因有贡献。本综述的主要目的是探讨 oPMNs 的产生和迁移到口腔腔道，它们的表型和在 OSCC 中可能扮演的角色。©2023。作者授权Springer Science+Business Media、LLC，属于Springer Nature专有许可。

Neutrophils are the predominant white blood cells (WBC) that are recruited to the sites of inflammation and infection. They are acknowledged to perform dual roles by promoting (pro-tumor) or by exhibiting anti-cancer properties (anti-tumor). Neutrophils are characterized based on the changes in phenotype and functional properties. To this context, circulating polymorphonuclear neutrophils (cPMN) and tumor-associated neutrophils (TANs) in cancer biology has been well explored but limited to oral polymorphonuclear neutrophils (oPMNs) in oral squamous cell carcinoma (OSCC). However, oPMNs are eminent in maintaining the healthy oral ecosystem by neutralizing microorganisms. Neutralization process enhances the expression of cell surface markers (CD11b, CD63, CD66, CD66b, CD66c, and CD66e) and inflammatory cytokines (TNF-α, IFN-γ, GM-CSF, and IL-8) and increases the recruitment of neutrophils. Along with the inflammation, it has been reported that CEACAM1 and chemerin also favors the infiltration of neutrophils to the cancer site. This indicates that oPMN might contribute to the aetiology of OSCC. The main objective of this review is to explore, the production and migration of oPMNs to the oral cavity, their phenotypes and possible role in OSCC.© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.