一种效率高的仿生纳米调节器，通过诱导钙离子/一氧化氮/能量代谢三重稳态紊乱实现协同治疗癌症。
An efficient biomimetic nano-regulator inducing simultaneous calcium ion/nitric oxide/energy metabolism triple homeostasis disruption for synergetic cancer therapy.
发表日期：2023 Apr 03
作者：
Chenchen Hu, Fan Jiang, Yixiao Li, Ruiyang Man, Zhengze Yu
来源：
Cellular & Molecular Immunology
摘要：
在癌细胞中诱导失衡的稳态将导致严重的细胞毒性和凋亡，用于癌症治疗。然而，全面的细胞内活性稳态机制使其仍然是一个令人生畏的挑战。本文报道了一种仿生纳米调节器，通过级联反应互相强化Ca2+/NO/能量代谢三重稳态失衡。
Inducing homeostasis disruption in cancer cells will cause severe cytotoxicity and apoptosis for cancer therapy. However, comprehensive intracellular active homeostatic mechanisms make it still a daunting challenge. Reported herein is a biomimetic nano-regulator for mutually reinforcing Ca2+/NO/energy metabolism triple homeostasis disruption via cascade reactions.