滴虫性阴道病是女性中最普遍的非病毒性性传播感染（STI）之一，并被认为是发展宫颈癌的风险因素之一。我们旨在研究T. vaginalis感染与宫颈癌发病之间的关联。于2021年10月21日，在五个数据库中进行了广泛的系统搜索。对评估T. vaginalis感染、HPV共感染、宫颈上皮内病变和宫颈癌之间关系的研究被认为有资格参与。采用随机效应模型计算了汇总比值比（ORs）及其95％置信区间（CIs）的摘要估计值。I2和Cochran的Q检验用于衡量统计异质性。29篇文章共纳入473,740名女性，其中8518例为T. vaginalis阳性。我们的结果显示，T. vaginalis感染女性诊断为HPV共感染的比例高出1.79倍（95％CI 1.27-2.53；I2 95％）。我们还发现，T. vaginalis感染与高级别鳞状上皮内病变（OR 2.34，95％CI 1.10-4.95；I2 75％）和宫颈癌（OR 5.23，95％CI 3.03-9.04；I2 3％）有关。我们的结果显示，T. vaginalis与性活跃女性的宫颈癌有关联。© 2023 The Authors. International Journal of Gynecology & Obstetrics，由John Wiley & Sons Ltd代表国际妇产科联合会出版。

Trichomonas vaginalis infection is the most prevalent non-viral sexually transmitted infection (STI) in women and has been suggested as a risk factor for developing cervical cancer.We aimed to investigate the associations between T. vaginalis infection and cervical carcinogenesis.A comprehensive systematic search was conducted in five databases on 21 October 2021.Studies assessing the relationship between T. vaginalis infection, HPV co-infections, cervical dysplasia, and cervical cancer were found eligible.Summary estimates for pooled odds ratios (ORs) and their 95% confidence intervals (CIs) were calculated with a random-effects model. Statistical heterogeneity was measured with I2 and Cochran's Q tests.The 29 articles included 473 740 women, of whom 8518 were T. vaginalis-positive. Our results showed that T. vaginalis-infected women had 1.79 times higher odds of being diagnosed with HPV co-infection (95% CI 1.27-2.53; I2 95%). We also found that T. vaginalis infection was associated with high-grade squamous intraepithelial lesion diagnosis (OR 2.34, 95% CI 1.10-4.95; I2 75%) and cervical cancer (OR 5.23, 95% CI 3.03-9.04; I2 3%).Our results showed an association between T. vaginalis and cervical carcinogenesis in sexually active women.© 2023 The Authors. International Journal of Gynecology & Obstetrics published by John Wiley & Sons Ltd on behalf of International Federation of Gynecology and Obstetrics.