消化道相关疾病的发病率正在上升，病因复杂。贵州石斛（学名：Noble Dendrobium Lindl.）是一种著名的中药，富含多种生物活性物质，已被证明对炎症和氧化应激相关的多种健康疾病有益。目前，虽然有各种治疗消化道疾病的临床药物可用，但耐药性的出现和多种副作用的存在需要开发新的药物以改善消化道疾病的效果。"Orchidaceae"、"Dendrobium"、"inflammation"、"digestive tract"和"polysaccharide"被用作搜索词来筛选文献。从Web of Science、PubMed、Elsevier、Science Direct和中国国家知识基础设施等在线数据库中获得了与消化道疾病相关的贵州石斛多糖和其他生物活性成分的治疗应用，以及列出的植物化学物质的已知药理作用相关信息。为了更好地利用贵州石斛预防和治疗与消化道相关的疾病，本综述总结了在消化道疾病管理中表现出潜在作用的贵州石斛生物活性成分及其潜在机制。研究表明，贵州石斛包括多种类别，包括多糖、酚类、生物碱、双苯乙烯、香豆素、苯并芘和类固醇，其中多糖是主要类别。贵州石斛对多种与消化道相关的疾病产生各种健康效应。其作用机制涉及抗氧化、抗炎、抗凋亡、抗癌，同时还调节了一些关键信号通路。总的来说，与目前的药物治疗相比，贵州石斛似乎是一种有前途的中药生物活性物质来源，有潜力进一步开发成营养保健品以治疗消化道疾病。本综述强调贵州石斛潜在的效应以及未来研究的前景，以最大限度地利用贵州石斛中的生物活性化合物治疗消化道疾病。本文还提供了贵州石斛生物活性成分及其提取和富集方法的汇编，以用于潜在的营养保健品中。版权所有 © 2023 Elsevier GmbH。

The incidence of diseases related to the digestive tract is on the rise, with many types of complex etiologies. Dendrobium nobile Lindl. is a famous Traditional Chinese Medicine (TCM) rich in many bioactives proven to be beneficial in several health diseases related to inflammation and oxidative stress.At present, despite the availability of various therapeutic clinical drugs used for the treatment of digestive tract diseases, resistance emergence and existence of several side effects warrant for the developing of novel drugs for improved effects on digestive tract diseases."Orchidaceae", "Dendrobium", "inflammation", "digestive tract", and "polysaccharide" were used as search terms to screen the literature. The therapeutic use of Dendrobium related to digestive tract diseases relative to known polysaccharides and other bioactive compounds were derived from online databases, including Web of Science, PubMed, Elsevier, Science Direct, and China National Knowledge Infrastructure, as well as relevant information on the known pharmacological actions of the listed phytochemicals.To better capitalize upon Dendrobium for preventing and treating diseases related to digestive tract, this review summarizes bioactives in Dendrobium reported of potential in digestive tract diseases management and their underlying action mechanisms. Studies revealed that Dendrobium encompasses diverse classes including polysaccharides, phenolics, alkaloids, bibenzyls, coumarins, phenanthrene and steroids, with polysaccharide as the major class. Dendrobium exerts various health effects on a variety of disease related to the digestive tract. Action mechanisms involve antioxidant, anti-inflammatory, anti-apoptotic, antioxidant, anticancer, alongside the regulation of some key signaling pathways.Overall, Dendrobium appears as a promising TCM source of bioactives that has the potential to be further developed into nutraceuticals for digestive tract diseases compared to current drug treatments. This review highlights for Dendrobium potential effects with future perspectives for needed future research to maximize the use of bioactive compounds from Dendrobium for digestive tract disease treatment. A compile of Dendrobium bioactives is also presented alongside methods for their extraction and enrichment for potential incorporation in nutraceuticals.Copyright © 2023. Published by Elsevier GmbH.