宫颈癌（CC）是妇女的一个重要公共卫生问题，其预防和治疗的观点和信息正在快速发展。人乳头瘤病毒（HPV）被认为是CC发展的主要贡献者，然而，HPV感染并不是CC唯一的原因。表观遗传学指由非基因序列改变引起的基因表达水平变化。越来越多的证据表明，表观遗传修饰所支配的基因表达模式的破坏可能导致癌症、自身免疫性疾病和各种其他疾病。本文主要从DNA甲基化、组蛋白修饰、非编码RNA调控和染色质调控等四个方面综述了CC中表观遗传修饰的当前研究现状，并讨论了它们在CC发生和进展中的功能和分子机制。这篇综述为CC的早期筛查、风险评估、分子靶向治疗和预后预测提供了新思路。版权所有©2023 Elsevier B.V. 出版。

Cervical cancer (CC) is an important public health problem for women, and perspectives and information regarding its prevention and treatment are quickly evolving. Human papilloma virus (HPV) has been recognized as a major contributor to CC development; however, HPV infection is not the only cause of CC. Epigenetics refers to changes in gene expression levels caused by non-gene sequence changes. Growing evidence suggests that the disruption of gene expression patterns which were governed by epigenetic modifications can result in cancer, autoimmune diseases, and various other maladies. This article mainly reviews the current research status of epigenetic modifications in CC based on four aspects, respectively DNA methylation, histone modification, noncoding RNA regulation and chromatin regulation, and we also discuss their functions and molecular mechanisms in the occurrence and progression of CC. This review provides new ideas for early screening, risk assessment, molecular targeted therapy and prognostic prediction of CC.Copyright © 2023. Published by Elsevier B.V.