在工作时暴露于化学物质的父母被认为是下一代患乳腺癌的潜在易感因素。此次全国范围内的巢式病例对照研究的目的是为这个领域提供证据。使用丹麦癌症登记处确定了原发性乳腺癌患者，并要求他们具有母亲或父亲就业史信息，共包括5587例。对于每个病例，使用丹麦民事登记系统匹配了出生年份的20个女性癌症自由对照组。工作史与职业化学物质暴露矩阵相关联，以评估特定的职业化学物质暴露。对于母亲暴露，我们观察到曾经接触柴油排放物（OR = 1.13，95% CI：1.01-1.27）和双酚A沥青烟雾暴露在围产期（OR = 1.51，95% CI：1.00-2.26）与乳腺癌有关联。最高累积暴露于苯并（a）芘，柴油排放物，汽油和双酚A沥青烟雾的风险进一步增加。结果进一步表明，柴油排放物（OR = 1.23，95% CI：1.01-1.50）和苯并（a）芘暴露（OR = 1.23，95% CI：0.96-1.57）与雌激素受体阴性肿瘤的关联比表达ER的肿瘤更强，而双酚A沥青烟雾似乎会提高两种激素亚型的风险。对于父亲的暴露，主要结果没有表明与乳腺癌有任何相关性。我们的研究表明，暴露于柴油排放物，苯并（a）芘和双酚A沥青烟雾等职业污染物的女性有患乳腺癌的风险升高。在任何确定之前，这些发现需要在未来的大规模研究中得到证实。版权所有 © 2023, Elsevier Inc. 发布。

Parental exposure to chemicals at work has been hypothesized to be a potential predisposing factor for breast cancer in next generations. The objective of the present nationwide nested case-control study was to contribute with evidence to this area.Women with primary breast cancer were identified using the Danish Cancer Registry and they were required to have information on either maternal or paternal employment history, which resulted in the inclusion of 5587 cases. For each case, 20 female cancer free controls were matched on year of birth using the Danish Civil Registration System. Employment history was linked to job exposure matrices to assess specific occupational chemical exposures.For maternal exposures, we observed an association between ever exposure to diesel exhaust (OR = 1.13, 95% CI: 1.01-1.27) and exposure to bitumen fumes in the perinatal period (OR = 1.51, 95% CI: 1.00-2.26) and breast cancer. Highest cumulative exposure to benzo(a)pyrene, diesel exhaust, gasoline and bitumen fumes was further indicated to increase the risk. Results further indicated a stronger association between diesel exhaust (OR = 1.23, 95% CI: 1.01-1.50) and benzo(a)pyrene exposure (OR = 1.23, 95% CI: 0.96-1.57) and estrogen receptor negative tumors than tumors with ER expression, while bitumen fumes seemed to elevate the risk of both hormonal subtypes. For paternal exposures, the main results did not indicate any associations with breast cancer.Our study suggests an elevated breast cancer risk in daughters of women occupational exposed to some occupational pollutants, including diesel exhaust, benzo(a)pyrene and bitumen fumes. These findings need to be confirmed in future large-scale studies before any firm conclusions can be reached.Copyright © 2023. Published by Elsevier Inc.