原发性皮肤鳞状细胞癌（CSCC）的风险因素已经得到了充分确认，但宿主和原发肿瘤风险因素对于随后的CSCC却没有得到充分探讨。我们对罗德岛一所学术性皮肤科诊所在2016年至2019年诊断的CSCC患者进行了回顾性病历审查。采用Logistic回归分析了宿主因素与多个CSCC之间的关联以及原发肿瘤特征与随后CSCC风险之间的关系。计算了调整后的赔率比（aORs）和95%置信区间（CIs）。共有1312名CSCC诊断患者被纳入研究。与多个CSCC明显相关的宿主风险因素包括：年龄>80岁（aOR 2.18，95% CI 1.46-3.31）和以下历史：固体器官移植（aOR 2.41，95% CI 1.20-4.80）；皮肤癌（aOR 1.96，95% CI 1.52-2.54）；其他癌症（aOR 1.49，95% CI 1.11-2.00）；家族皮肤癌（aOR 1.36，95% CI 1.03-1.78）；日光性角化症（aOR 1.52，95% CI 1.18-1.95）。肿瘤位置、直径、组织学分化和治疗并不是随后CSCC的显著预测因素。研究患者主要是白种人，而且来自单一机构，限制了结果的普适性。特定的宿主特征与随后CSCC的发展有关，这可能有助于制定临床随访指南。 版权所有 © 2023 Elsevier Inc. 发表。

Risk factors for a primary cutaneous squamous cell carcinoma (CSCC) are well-established, but host and primary tumor risk factors for subsequent CSCC have not been fully explored.We performed a retrospective chart review of patients diagnosed with CSCC in an academic dermatology clinic in Rhode Island from 2016-2019. Logistic regression was used to evaluate the associations between host factors and multiple CSCC and between primary tumor characteristics and risk of subsequent CSCC. Adjusted odds ratios (aORs) and 95% confidence intervals (CIs) were calculated.1,312 patients with CSCC diagnoses were included. Host risk factors significantly associated with multiple CSCCs included: age >80 (aOR 2.18, 95% CI 1.46-3.31) and history of: solid organ transplant (aOR 2.41, 95% CI 1.20-4.80); skin cancer (aOR 1.96, 95% CI 1.52-2.54); other cancer (aOR 1.49, 95% CI 1.11-2.00); family skin cancer (aOR 1.36, 95% CI 1.03-1.78); actinic keratosis (aOR 1.52, 95% CI 1.18-1.95). Tumor location, diameter, histologic differentiation, and treatment were not significant predictors of subsequent CSCCs.Study patients were predominantly Caucasian and from a single institution, limiting the generalizability of results.Certain host characteristics were associated with development of subsequent CSCC, which may inform clinical guidelines for follow-up.Copyright © 2023. Published by Elsevier Inc.