通过CT和MRI来定义肝病患者中的肌肉量减少性肥胖症（SaO），并评估其对肝病严重程度的影响。本研究纳入来自胃肠病和肝病科门诊的慢性乙型肝炎（N：101）、肝硬化（N：110）和肝细胞癌（N：169）患者，这些患者在进行CT或MRI扫描前的两周内有身高、体重、Child-Pugh和MELD评分的相关信息。回顾性地评估这些患者的横断面检查中骨骼肌指数（SMI）和内脏脂肪组织面积（VATA），并通过Child-Pugh和MELD评分来评估疾病的严重程度。肝硬化患者中的肌肉量减少症和SaO率均高于慢性乙型肝炎患者（分别为p＜0.033和p＜0.004）。肝细胞癌患者中的肌肉量减少症和SaO率也高于慢性乙型肝炎患者（分别为p＜0.001和p＜0.001）。患有肌肉量减少症的慢性乙型肝炎、肝硬化和肝细胞癌患者的MELD评分均高于无肌肉量减少症的患者（分别为p＜0.035、p＜0.023和p＜0.024）。尽管在肝硬化和肝细胞癌患者中，肌肉量减少症患者的Child-Pugh评分增加类似，但结果在统计上不显著（p＜0.597和p＜0.688）。肝细胞癌患者中患有SaO的患者的MELD评分高于其他体成分类别的患者（p＜0.006）。肝硬化患者中患有SaO的患者的MELD评分高于无肌肉量减少肥胖症的患者（p＜0.049）。患有肥胖症的慢性乙型肝炎患者MELD评分低（p＜0.035）。患有肥胖症的肝硬化和肝细胞癌患者的MELD评分高于非肥胖症患者，但只有肝细胞癌患者具有统计学意义（p＜0.480和p＜0.001）。通过对SaO的放射学评估，并将体成分与MELD评分协调，对CLD的管理至关重要。opyright © 2023 The Association of University Radiologists. Published by Elsevier Inc. All rights reserved.

To define sarcopenic obesity (SaO) among chronic liver disease (CLD) patients via CT and MRI, and assess its impact on liver disease severity.CLD patients referred from the Gastroenterology and Hepatology Department diagnosed as chronic hepatitis B (N:101), cirrhosis (N:110), and hepatocellular carcinoma (N:169) with available information on body height, weight, Child-Pugh and MELD scores within 2 weeks of CT or MRI scanning were included in the study. Cross-sectional examinations were retrospectively evaluated for skeletal muscle index (SMI) and visceral adipose tissue area (VATA). The disease severity was assessed by Child-Pugh and MELD scoring.The rate of sarcopenia and SaO in the cirrhotic patients was higher than that in the chronic hepatitis B patients (p <0.033 and p < 0.004, respectively). The rate of sarcopenia and SaO in HCC patients was higher than that in the chronic hepatitis B patients (p <0.001 and p <0.001, respectively). Sarcopenic patients in Chronic hepatitis B, cirrhotic, and HCC groups had higher MELD scores than nonsarcopenic patients (p <0.035, p <0.023, and p <0.024, respectively). Despite finding a similar increase in Child-Pugh scores in cirrhotic and HCC sarcopenic patients, results were statistically insignificant (p <0.597 and p <0.688). HCC patients with SaO had higher MELD scores than patients with other body composition catagories (p <0.006). Cirrhotic patients with SaO had higher MELD scores than nonsarcopenic obese patients (p <0.049). Chronic hepatitis B patients with obesity had low MELD scores (p <0.035). Cirrhotic and HCC patients with obesity had higher MELD scores (p <0.01 and p <0.024, respectively). Cirrhotic and HCC patients with obesity had higher Child-Pugh scores than nonobese patients but only HCC patients showed statistically significance (p <0.480 and p <0.001).Radiologic evaluation of SaO and harmonizing body composition with MELD scoring is critical in CLD management.Copyright © 2023 The Association of University Radiologists. Published by Elsevier Inc. All rights reserved.