鉴于其多功能性和广泛的应用领域，核壳结构纳米颗粒（NPs）引起了相当大的关注。本文提出了一种新颖的混合技术合成ZnO@NiO核壳结构纳米颗粒的方法。表征证明成功形成了平均晶粒尺寸为13.059 nm的ZnO@NiO核壳结构纳米颗粒。结果表明，制备出的NPs对革兰氏阴性和革兰氏阳性细菌都具有优异的抗菌活性。这种行为主要是由于ZnO@NiO NPs在细菌表面的积聚，导致细菌细胞毒性增加，ZnO相对增加，从而导致细胞死亡。此外，使用ZnO@NiO核壳结构材料将防止细菌在培养基中营养自给。最后，PLAL是一种易于扩展、费用效益高、环保的NPs合成方法，制备的核壳结构NPs可以用于其他生物应用，如药物传递、癌症治疗和进一步的生物医学功能化。©2023年。作者等。

Given their versatile nature and wide range of possible applications, core-shell nanoparticles (NPs) have received considerable attention. This paper proposes a novel method for synthesizing ZnO@NiO core-shell nanoparticles using a hybrid technique. The characterization demonstrates the successful formation of ZnO@NiO core-shell nanoparticles, which have an average crystal size of 13.059 nm. The results indicate that the prepared NPs have excellent antibacterial activity against both Gram-negative and Gram-positive bacteria. This behavior is primarily caused by the accumulation of ZnO@NiO NPs on the bacteria's surface, which results in cytotoxic bacteria and a relatively increased ZnO, resulting in cell death. Moreover, the use of a ZnO@NiO core-shell material will prevent the bacteria from nourishing themselves in the culture medium, among many other reasons. Finally, the PLAL is an easily scalable, cost-effective, and environmentally friendly method for the synthesis of NPs, and the prepared core-shell NPs could be used in other biological applications such as drug delivery, cancer treatment, and further biomedical functionalization.© 2023. The Author(s).