在乳腺癌（BC）中缺乏雌激素受体、孕激素受体和人表皮生长因子受体-2的表达是将肿瘤分类为三阴性乳腺癌（TNBC）的基础。大多数TNBC是侵袭性肿瘤，常见转移和降低的标记物表达，这些标记物可以帮助识别转移病灶是否来源于乳腺。乳腺标记物（如大囊性疾病液体蛋白-15（GCDPF-15）、GATA结合蛋白3（GATA3）、乳球蛋白（MGB）和SOX10）并不是唯一特异于BC的标记物。我们的目的是在一系列细胞角蛋白-5表达的TNBC中评估三指毛鼻脚综合征1型（TRPS1）蛋白作为乳腺标记物，这些前期已经表征了其他乳腺标记物的表达。在组织微阵列中，对117个TNBC进行了TRPS1免疫染色。阳性的分界值为≥10%。还评估了这种分类的可再现性。在92/117（79%）的病例中检测到TRPS1阳性表达，这超过了之前测试的标记物表达，如SOX10的82（70％），GATA3的11（9％），MGB的10（9％）和GCDFP-15的7（6％）。在25个TRPS1阴性病例中，11个病例与SOX10阳性相关，而5至6个二重阴性病例仍对其他标记物呈阳性。评估显示了实质性的一致性。在比较的五个标记物中，TRPS1似乎是CK5表达的TNBC的乳腺起源最敏感的标记物。通常将阴性病例标记为SOX10，其余病例仍可能对任何其他三种标记物表现出阳性。 TRPS1在乳腺标记物组中具有作用。©2023年。作者。

The lack of oestrogen receptor, progesterone receptor and human epidermal growth factor receptor-2 expression in breast cancer (BC) is the basis for the categorization of the tumour as triple negative breast carcinoma (TNBC). The majority of TNBCs are aggressive tumours with common metastases and decreased expression of markers that could help in identifying the metastatic lesion as of mammary origin. Breast markers, such as gross cystic disease fluid protein-15 (GCDPF-15), GATA binding protein 3 (GATA3), mammaglobin (MGB) and SOX10, are not uniquely specific to BC. Our aim was to evaluate trichorhinophalangeal syndrome type 1 (TRPS1) protein as a breast marker in a series of cytokeratin-5-expressing TNBC, mostly corresponding to basal-like TNBCs, previously characterized for the expression of other breast markers. One hundred seventeen TNBCs in tissue microarrays were immunostained for TRPS1. The cut-off for positivity was ≥ 10%. The reproducibility of this classification was also assessed. TRPS1 positivity was detected in 92/117 (79%) cases, and this exceeded the expression of previously tested markers like SOX10 82 (70%), GATA3 11 (9%), MGB 10 (9%) and GCDFP-15 7 (6%). Of the 25 TRPS1-negative cases, 11 were positive with SOX10, whereas 5 to 6 dual negatives displayed positivity for the other makers. The evaluation showed substantial agreement. Of the five markers compared, TRPS1 seems the most sensitive marker for the mammary origin of CK5-expressing TNBCs. Cases that are negative are most often labelled with SOX10, and the remainder may still demonstrate positivity for any of the 3 other markers. TRPS1 has a place in breast marker panels.© 2023. The Author(s).