正电子发射断层扫描（PET） /计算机断层扫描（CT）成像技术可以检测动脉炎症的变化，但尚未用于评估化疗引起的静脉炎症或评估儿科肿瘤患者静脉血栓栓塞（VTE）的风险。因此，本研究的目的是评估荧光-18-氟脱氧葡萄糖PET / CT成像技术评估静脉炎症的预后价值，以预测在儿童、青少年和成年患者淋巴瘤诊断后的12个月内VTE发生的情况。 回顾性评估了淋巴瘤诊断（n = 71）的儿童、青少年和成年患者在疾病初期分期和第一次治疗后随访的全身PET / CT成像。使用PET / CT图像对有兴趣的静脉（即腘动脉和股动脉）进行分割和量化以检测氟-18-氟脱氧葡萄糖摄取量的连续变化。在淋巴瘤诊断后的12个月内评估了VTE的发生率。 PET / CT检测到与没有VTE的患者相比，在VTE事件发生的患者的股动脉（P = 0.012）和腘动脉（P = 0.013）静脉中有显著更高的炎症反应。基于VTE的发生率，接收器操作特征曲线分析的曲线下面积值分别为0.76（股动脉）和0.77（腘动脉）。单变量分析表明，PET / CT测得的股动脉（P = 0.008）和腘动脉（P = 0.002）的炎症变化与VTE发生率12个月后的生存率显著相关。 荧光-18-氟脱氧葡萄糖PET / CT成像技术可以检测到治疗引起的静脉毒性，这可能为患有淋巴瘤的儿童、青少年和成年患者的VTE事件风险提供洞察。

Positron emission tomography (PET)/computed tomography (CT) imaging can detect changes in arterial inflammation, but has not been used to evaluate chemotherapy-induced venous inflammation or assess risk for venous thromboembolism (VTE) in pediatric oncology. Therefore, the purpose of this study was to evaluate the prognostic value of fluorine-18-fluorodeoxyglucose PET/CT imaging of venous inflammation for predicting VTE occurrence in the 12 months after lymphoma diagnosis in pediatric, adolescent, and young adult patients.Pediatric, adolescent, and young adult patients with lymphoma diagnoses (n=71) who underwent whole-body PET/CT imaging at initial staging of disease and first therapeutic follow-up were retrospectively evaluated for serial changes in lower extremity venous uptake of fluorine-18-fluorodeoxyglucose. PET/CT images were used to segment and quantify serial changes in fluorine-18-fluorodeoxyglucose uptake for veins of interest (ie, popliteal and femoral). Incidence of VTE was assessed for 12 months after lymphoma diagnosis.PET/CT detected a significantly higher inflammatory response in the femoral (P=0.012) and popliteal (P=0.013) veins of patients who experienced a VTE event compared with those who remained VTE free in the 12 months after diagnosis. The area under the curve values for receiver operator characteristics analyses were 0.76 (femoral vein) and 0.77 (popliteal vein) based on incidence of VTE occurrence. Univariate analyses demonstrated that PET/CT-derived changes in femoral (P=0.008) and popliteal (P=0.002) vein inflammation were significantly associated with VTE-free survival at 12 months after diagnosis.Fluorine-18-fluorodeoxyglucose PET/CT imaging detects treatment-induced venous toxicity that may provide insight into risk of VTE events in pediatric and adolescent and young adult patients with lymphoma.