胰腺癌的发病率在发达和发展中国家都在增加。近年来，各种研究证据表明，重新编程代谢可能在胰腺癌肿瘤发生和发展中发挥关键作用。因此，它具有作为诊断、预后和治疗靶点的巨大潜力。氨基酸代谢在胰腺癌中发生了变化，氨基酸代谢的改变可能影响癌细胞状态、恶性肿瘤患者的全身代谢，还可能错误地参与干细胞性、增殖和生长、侵袭和迁移、氧化还原状态维持、自噬、细胞凋亡，甚至肿瘤微环境相互作用等不同的生物过程。总体而言，以上作用是通过两个途径实现的，即能量代谢和信号转导。本综述旨在强调目前关于胰腺癌氨基酸代谢异常变化的研究进展，它们如何影响胰腺癌的肿瘤发生和发展，以及它们作为诊断、预后和治疗靶点的应用前景。版权所有 ©2023 Elsevier B.V.。

The incidence of pancreatic cancer is increasing in both developed and developing Nations. In recent years, various research evidence suggested that reprogrammed metabolism may play a key role in pancreatic cancer tumorigenesis and development. Therefore, it has great potential as a diagnostic, prognostic and therapeutic target. Amino acid metabolism is deregulated in pancreatic cancer, and changes in amino acid metabolism can affect cancer cell status, systemic metabolism in malignant tumor patients and mistakenly involved in different biological processes including stemness, proliferation and growth, invasion and migration, redox state maintenance, autophagy, apoptosis and even tumor microenvironment interaction. Generally, the above effects are achieved through two pathways, energy metabolism and signal transduction. This review aims to highlight the current research progress on the abnormal alterations of amino acids metabolism in pancreatic cancer, how they affect tumorigenesis and development of pancreatic cancer and the application prospects of them as diagnostic, prognostic and therapeutic targets.Copyright © 2023 Elsevier B.V. All rights reserved.