乳腺癌患者和幸存者常常报告认知功能降低，但这种下降的机制尚未确定。我们比较了年龄和体重指数匹配的乳腺癌幸存者（n = 15）和癌症自由女性（n = 15）的脑血管功能和认知差异。参与者接受了人体测量、情绪、心血管、运动表现、力量、脑血管和认知测量。采用经颅多普勒超声测量脑血管对生理（高碳酸盐血症；5％二氧化碳）和心理刺激的反应（CVR）。乳腺癌幸存者的高碳酸盐血症CVR（21.5 ± 12.8 vs 66.0 ± 20.9％，P＜0.001）、认知刺激CVR（15.1 ± 1.5 vs 23.7 ± 9.0％，P＜0.001）和总体认知复合评分（100 ± 12 vs 113 ± 7，P = 0.003）均显著低于癌症自由女性。这些参数在使用协变量分析进行调整后，两组之间仍然存在显着差异。我们观察到多种测量数据和运动能力之间的显着相关性，只有运动能力这一变量与所有主要测量指标呈正相关（高碳酸盐血症CVR，r = 0.492，P = 0.007;认知刺激CVRr = 0.555，P = 0.003;总体认知复合分数r = 0.625，P＜ 0.001）。在本研究中，乳腺癌幸存者的脑血管和认知功能低于同龄的癌症自由女性，这可能归因于癌症和癌症治疗对脑健康的影响。Crown Copyright © 2023。Elsevier Ltd.发表。版权所有。

Reduced cognition is often reported by breast cancer patients and survivors, but the mechanisms for this decline are yet to be determined. We compared the differences in cerebrovascular function and cognition in breast cancer survivors (n = 15) and cancer-free women (n = 15) matched by age and body mass index. Participants undertook anthropometric, mood, cardiovascular, exercise performance, strength, cerebrovascular, and cognitive measurements. Transcranial Doppler ultrasound was used to measure the cerebrovascular responsiveness (CVR) to physiological (hypercapnia; 5% carbon dioxide) and psychological stimuli. Breast cancer survivors had a lower CVR to hypercapnia (21.5 ± 12.8 vs 66.0 ± 20.9%, P < 0.001), CVR to cognitive stimuli (15.1 ± 1.5 vs 23.7 ± 9.0%, P < 0.001) and total composite cognitive score (100 ± 12 vs. 113 ± 7, P = 0.003) than cancer-free women. These parameters remained statistically different between the groups following adjustments for covariates using an analysis of co-variance. We observed significant correlations between multiple measures and exercise capacity the only variable positively correlated to all primary measures (CVR to hypercapnia, r = 0.492, P = 0.007; CVR to cognitive stimuli r = 0.555, P = 0.003; and total composite cognitive score, r = 0.625, P < 0.001). In this study, breast cancer survivors had lower cerebrovascular and cognitive function than age-matched cancer-free women, which may be attributable to the effects of cancer and cancer treatment on brain health.Crown Copyright © 2023. Published by Elsevier Ltd. All rights reserved.