来自扁担杆科植物Strophanthus divaricatus茎的细胞毒性类固醇。
Cytotoxic steroids from the stems of Strophanthus divaricatus.
发表日期：2023 Apr 04
作者：
Hong-Ling Ran, Sheng-Zhuo Huang, Hao Wang, Li Yang, Cui-Juan Gai, Rui-Jun Duan, Hao-Fu Dai, Ya-Li Guan, Wen-Li Mei
来源：
PHYTOCHEMISTRY
摘要：
对Strophanthus divaricatus茎进行植物化学研究，分离出四种未描述的心脏甙和一种未描述的C21孕烷，以及11种已知的类固醇。通过全面分析HRESIMS、1D和2D NMR光谱谱图来阐明它们的结构。通过比较实验和计算的ECD光谱来确定16的绝对配置。化合物1-13和15对人类癌细胞系K562、SGC-7901、A549和HeLa表现出有效到显著的细胞毒性，IC50值分别为0.02-16.08、0.04-23.13、0.06-22.31和0.06-15.13μM。Copyright © 2023 Elsevier Ltd. All rights reserved.
Phytochemical investigation on the stems of Strophanthus divaricatus led to the isolation of four undescribed cardiac glycosides and one undescribed C21 pregnane, together with eleven known steroids. Their structures were elucidated by a comprehensive analysis of HRESIMS, 1D and 2D NMR spectra. The absolute configuration of 16 was determined by comparison of the experimental and computed ECD spectra. Compounds 1-13 and 15 displayed potent to significant cytotoxicity against human cancer cell lines K562, SGC-7901, A549 and HeLa with IC50 values of 0.02-16.08, 0.04-23.13, 0.06-22.31 and 0.06-15.13 μM, respectively.Copyright © 2023 Elsevier Ltd. All rights reserved.