肿瘤细胞释放的含非编码RNA外泌体在调节免疫细胞功能及其由实验室到临床的意义中的作用。
The role of tumor-derived extracellular vesicles containing noncoding RNAs in mediating immune cell function and its implications from bench to bedside.
发表日期：2023 Apr 03
作者：
Chen-Guang Liu, Jun Chen, Robby Miguel Wen-Jing Goh, Yu-Xuan Liu, Lingzhi Wang, Zhaowu Ma
来源：
PHARMACOLOGICAL RESEARCH
摘要：
细胞外囊泡（EVs）是由几乎所有细胞释放的被膜包裹的小囊泡，通过传递不同类型的分子货物，如非编码RNA（ncRNAs），参与细胞间通讯。越来越多的证据表明，肿瘤来源的EVs作为肿瘤细胞和周围细胞（包括免疫细胞）之间细胞间相互作用的桥梁。肿瘤来源的EVs含有ncRNAs（TEV-ncRNAs），通过介导细胞间相互作用来操纵免疫反应并影响癌细胞的恶性表型。在本综述中，我们总结TEV-ncRNAs在调节先天性和适应性免疫细胞中的双重作用和潜在机制。我们还强调了在癌症诊断和预后方面使用TEV-ncRNAs的优势。此外，我们概述了使用改良的EVs传递ncRNAs和其他治疗药物用于癌症治疗。 版权所有©2023作者。由Elsevier Ltd.出版。保留所有权利。
Extracellular vesicles (EVs) are membrane-encapsulated vesicles released by almost all cell types, which participate in intercellular communication by delivering different types of molecular cargoes, such as non-coding RNAs (ncRNAs). Accumulating evidence suggests that tumor-derived EVs act as a bridge for intercellular crosstalk between tumor cells and surrounding cells, including immune cells. Tumor-derived EVs containing ncRNAs (TEV-ncRNAs) mediate intercellular crosstalk to manipulate immune responses and affect the malignant phenotypes of cancer cells. In this review, we summarize the double-edged roles and the underlying mechanisms of TEV-ncRNAs in regulating innate and adaptive immune cells. We also highlight the advantages of using TEV-ncRNAs in liquid biopsies for cancer diagnosis and prognosis. Moreover, we outline the use of engineered EVs to deliver ncRNAs and other therapeutic agents for cancer therapy.Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.