为确定术前在家运动计划对胰腺癌患者的健康和身体功能的影响，我们先前发现高频率的肌肉萎缩和虚弱。在这个随机对照试验(NCT03187951)中，患有胰腺癌的患者被随机分为A组：强化常规护理或B组：术前新辅助治疗期间进行有氧和抗阻力锻炼。患者接受营养咨询和活动追踪器。主要终点是6分钟步行距离(6MWD，≥14米改善有临床意义)。次要终点包括其他身体功能测试、健康相关生命质量和临床结果。151名患者被随机分组。客观测量的每周活动(分别为A组153.2±135.6和B组159.8±122.8分钟，P=0.62)和自报的每周中度至剧烈体力活动(分别为A组107.4±160.4和B组129.6±161.6分钟，P=0.49)相似，但强度训练课程每周更多地增加在B组(0.1±2.4次比1.8±1.8次，P<0.001)。6MWD在A组(平均变化18.6±56.8米，P=0.01)和B组(27.3±68.1米，P=0.002)均有改善。生活质量和临床结果在两组之间没有显著差异。在合并两个研究组的患者中，运动和体力活动与身体表现和临床结果有利相关。在胰腺癌新辅助治疗期间进行处方锻炼与强化常规护理相比，两组都观察到了高活动量和增加的锻炼能力，突显术前患者进行体力活动的重要性。版权所有©2023 Wolters Kluwer Health, Inc.。保留所有权利。

To determine the effects of a preoperative, home-based exercise program on fitness and physical function in patients with pancreatic cancer.We previously established a well-tolerated preoperative exercise program after finding a high frequency of sarcopenia and frailty in patients with pancreatic cancer.In this randomized, controlled trial (NCT03187951), patients with pancreatic cancer were randomized to Arm A: enhanced usual care or Arm B: prescribed aerobic and resistance exercise during neoadjuvant therapy. Patients received nutrition counseling and activity trackers. The primary endpoint was 6-minute walk distance (6MWD; ≥14 meters improvement was clinically meaningful). Secondary endpoints included additional physical function tests, health-related quality of life, and clinical outcomes.151 patients were randomized. Objectively measured weekly activity (153.2±135.6 and 159.8±122.8 min in Arm A and B, respectively, P=0.62) and self-reported weekly moderate-to-strenuous physical activity (107.4±160.4 and 129.6±161.6 min in Arm A and Arm B, respectively, P=0.49) were similar, but weekly strength training sessions increased more in Arm B (by 1.8±1.8 vs. 0.1±2.4 sessions, P<0.001). 6MWD improved in both Arm A (mean change 18.6±56.8 m, P=0.01) and Arm B (27.3±68.1 m, P=0.002). Quality of life and clinical outcomes did not significantly differ between arms. Pooling patients in both study groups, exercise and physical activity were favorably associated with physical performance and clinical outcomes.In this randomized trial of prescribed exercise versus enhanced usual care during neoadjuvant therapy for pancreatic cancer, high volume of activity and increased exercise capacity were observed in both arms, highlighting the importance of activity among patients preparing for surgery.Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.