颗粒细胞瘤（GCT）通常出现在皮下组织和头颈部位，而在胃肠道中不常见。儿科食管GCT的经验很有限，在文献中仅有7例报道，其中3例有嗜酸性食管炎（EoE）。收集了11名儿童食管GCT病例资料。从所有病人的临床、内镜和随访数据中回顾了H＆E和免疫组化切片。共纳入7名男性和4名女性患者，年龄范围为3至14岁。胃食管十二指肠镜（EGD）的指征包括EoE（n = 3）、对Crohn病的随访和其他非特异性投诉。内窥镜检查显示，所有病人都有单个的粘膜下、坚实的肿块突出到腔内，覆盖上皮正常。所有病例均采用内窥镜多次碎片切除。组织学上，肿瘤显示出细胞片和小梁，包含无印记核、不明显的核仁和丰富的粉红色颗粒质细胞，没有非典型特征。所有肿瘤对S100、CD68和SOX10呈免疫反应性。随访结果显示，所有患者病情稳定（中位随访2年）。我们报道了最大的儿科食管GCT病例系列，其中与EoE并发关联。这些EGD检查发现是特征性的，通过活检切除既有诊断也有治疗作用。©作者（们）2023年。由牛津大学出版社代表美国临床病理学会出版。保留所有权利。有关权限，请发送电子邮件至: journals.permissions@oup.com。

Granular cell tumor (GCT) commonly presents in the subcutaneous tissue and head and neck region, and it is uncommon in the gastrointestinal tract. Experience with esophageal GCTs in the pediatric population is limited, with only 7 cases reported in the literature, 3 with eosinophilic esophagitis (EoE).Case information from 11 pediatric patients with GCTs of the esophagus was retrieved. H&E and immunohistochemical slides were reviewed with clinical, endoscopic, and follow-up data from all patients.In total, 7 male and 4 female patients were included, with ages ranging from 3 to 14 years. Indications for esophagogastroduodenoscopy (EGD) included EoE (n = 3), follow-up for Crohn disease, and other nonspecific complaints. Endoscopically, all patients had a single submucosal, firm mass protruding into the lumen, with normal overlying mucosa. The nodules were removed endoscopically in multiple fragments in all cases. Histologically, the tumors showed sheets and trabeculae of cells containing bland nuclei, inconspicuous nucleoli, and abundant pink granular cytoplasm without atypical features. All tumors were immunoreactive for S100, CD68, and SOX10. Follow-up showed that all patients were disease-free (median, 2 years).We report the largest series of pediatric esophageal GCTs with coincidental association with EoE. These EGD findings are characteristic, and removal by biopsy is both diagnostic and therapeutic.© The Author(s) 2023. Published by Oxford University Press on behalf of American Society for Clinical Pathology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.