Glypican-3（GPC3）是一种细胞表面糖蛋白，在肝细胞癌中经常过度表达。GPC3经历大量的翻译后修饰，包括剪切和糖基化。本综述聚焦于肝癌中GPC3的结构和功能，突出了GPC3三级和四级结构的翻译后修饰作为潜在的致癌调节机制。我们提出，在正常发育中，GPC3的功能可以因广泛的翻译后修饰而有所不同，这些过程的失调会导致疾病。定义这些修饰的调节影响可以更深入地了解GPC3在肿瘤发生、上皮间质转化和药物开发中的作用。通过对当前文献的回顾，本文提供了一个独特的视角，关注GPC3在肝癌中的作用，重点关注翻译后修饰对GPC3功能在分子、细胞和疾病水平的潜在调节机制。

Glypican-3 (GPC3) is a cell-surface glycoprotein that is frequently overexpressed in hepatocellular carcinoma. GPC3 undergoes extensive post-translational modification including cleavage and glycosylation. This review focuses on the structure and function of GPC3 in liver cancer, highlighting the post-translation modification (PTM) of the tertiary and quaternary structures of GPC3 as a potential oncogenic regulatory mechanism. We propose that the function of GPC3 in normal development can vary with extensive PTM and that dysregulation of these processes leads to disease. Defining the regulatory impact of these modifications can provide a deeper understanding of the role of GPC3 in oncogenesis, epithelial-mesenchymal transition, and drug development. Through review of current literature, this paper provides a unique perspective on the role of GPC3 in liver cancer, focusing on potential regulatory mechanisms of post-translational modifications on GPC3 function at the molecular, cellular, and disease level.