肺癌多年来一直是全球癌症死亡率的主要原因。本研究旨在调查肺癌的全球模式和趋势。肺癌发病率和死亡率来自GLOBOCAN 2020数据库。用《五大洲癌症发病率时间趋势》的连续数据使用Joinpoint回归分析2000年至2012年的时间趋势，并计算平均年百分比变化率。通过线性回归评估人类发展指数与肺癌发病率和死亡率之间的关联。预计2020年有220万例新的肺癌病例和180万肺癌相关死亡。年龄标准化发病率（ASIR）在丹麦为每10万人36.8例，而在墨西哥为5.9例。年龄标准化死亡率（ASMR）在波兰为每10万人32.8例，而在墨西哥为4.9例。男性的ASIR和ASMR均约为女性的两倍。在2000年至2012年间，美国肺癌的ASIR呈下降趋势，男性的趋势更为明显。50至59岁的人口中，中国男女肺癌年龄特定发病率均呈上升趋势。肺癌的负担仍然不令人满意，特别是在中国这样的发展中国家。考虑到烟草控制和筛查在美国等发达国家的有效性，有必要加强健康教育，加快制定烟草控制政策和法规，并提高早期癌症筛查的意识，以减轻未来肺癌的负担。版权所有©2023年中国医师协会，由Wolters Kluwer，Inc.根据CC-BY-NC-ND许可生产。

Lung cancer has been the leading cause of cancer-related deaths worldwide for many years. This study aimed to investigate the global patterns and trends of lung cancer.Lung cancer incidence and mortality were derived from the GLOBOCAN 2020 database. Continuous data from Cancer Incidence in Five Continents Time Trends were used to analyze the temporal trends from 2000 to 2012 using Joinpoint regression, and average annual percent changes were calculated. The association between the Human Development Index and lung cancer incidence and mortality was assessed by linear regression.An estimated 2.2 million new lung cancer cases and 1.8 million lung cancer-related deaths occurred in 2020. The age-standardized incidence rate (ASIR) ranged from 36.8 per 100,000 in Demark to 5.9 per 100,000 in Mexico. The age-standardized mortality rate (ASMR) varied from 32.8 per 100,000 in Poland to 4.9 per 100,000 in Mexico. Both ASIR and ASMR were approximately twice higher in men than in women. The ASIR of lung cancer showed a downward trend in the United States of America (USA) between 2000 and 2012, and was more prominent in men. The age-specific incidence rates of lung cancer for ages of 50 to 59 years showed an upward trend in China for both men and women.The burden of lung cancer is still unsatisfactory, especially in developing countries like China. Considering the effectiveness of tobacco control and screening in developed countries, such as the USA, there is a need to strengthen health education, accelerate the establishment of tobacco control policies and regulations, and improve early cancer screening awareness to reduce the future burden of lung cancer.Copyright © 2023 The Chinese Medical Association, produced by Wolters Kluwer, Inc. under the CC-BY-NC-ND license.