肝切除术对于患有结直肠肝转移瘤的患者具有潜在治愈作用，但对肿瘤生物学的高级理解和改进的辅助治疗促进了转移切除手术的不断进化，即使在存在显著转移病变负担的情况下也是如此。随着手术指征的扩大，对于优选的技术和时间也在进行着讨论。本文评估了对结直肠肝转移瘤切除的解剖学与非解剖学方法的优点，考虑了肿瘤学结果、总生存率和转移性肝脏扩散的病理生理学相冲突的理论。版权所有 © 2023 Elsevier Inc.。保留所有权利。

Liver resection is potentially curative for patients with colorectal liver metastasis, but an advanced understanding of tumor biology and improved adjuvant therapies have facilitated an ongoing evolution of metastatic resection, even in the setting of a significant metastatic disease burden. As indications for surgery have expanded, preferred techniques and timing have been debated. This commentary reviews the merits of anatomic versus non-anatomic approaches to colorectal liver metastasis resection, considering oncologic outcomes, overall survival, and conflicting theories in the pathophysiology of the metastatic liver spread.Copyright © 2023 Elsevier Inc. All rights reserved.