研究动态
Articles below are published ahead of final publication in an issue. Please cite articles in the following format: authors, (year), title, journal, DOI.

晚期癌症姑息治疗患者的运动干预:随机对照试验的系统性文献综述和描述性证据综合。

Exercise interventions for advanced cancer palliative care patients: A systematic literature review and descriptive evidence synthesis of randomized controlled trials.

发表日期:2023 Apr 08
作者: India Rogers-Shepp, Souradeep Bhattacharya, Haran A Mennillo, Ritika Kumar, Ben Hsieh, Gowri Anandarajah
来源: PALLIATIVE MEDICINE

摘要:

运动经常被建议给癌症患者。然而,对于晚期癌症姑息治疗患者来说,作为一种生活方式干预,运动是否有益于姑息结果尚不清楚。为了检查评估先进癌症患者姑息结果的生活方式运动干预的随机对照试验。系统评价和描述性证据综合分析。Pubmed/Medline、Embase、CINAHL、PsychInfo和Web of Science从成立到2022年被系统搜索。两位评审人员确定文章并删除重复文章。接下来,两位评审人员独立筛选标题和摘要,然后评估符合条件的全文文章。最后,所有六位评论者检查了符合条件的全文文章,并进行了证据综合。包括8个随机对照试验。研究不均匀,使直接比较具有挑战性,但分为三类:有氧,抗阻或抗阻氧混合运动。三项有氧运动之一具有积极的生活质量结果。在一个有氧运动和一个抗阻混合运动研究中,疲劳有所改善。大多数抗阻混合运动研究和一个有氧运动研究显示了改善体能功能。所有抗阻研究都显示在至少一项结果上有改善。在所有研究中,健康状况是参与者退出的最常见原因。最常用的评估工具是:癌症治疗功能评估:疲劳,欧洲肿瘤治疗组织生活质量问卷核心30和加速计。有关运动干预对晚期癌症患者姑息结果的影响的当前随机对照试验显示出极大的变异性。尽管研究表现出希望,但不能得出普遍的结论。需要进一步研究。
Exercise is often recommended for cancer patients. However, for advanced cancer palliative care patients, it is unclear whether exercise, as a lifestyle intervention, is beneficial for palliative outcomes.To examine randomized controlled trials assessing the effectiveness of lifestyle exercise interventions on palliative outcomes in patients with advanced stage cancer.Systematic review and descriptive evidence synthesis.Pubmed/Medline, Embase, CINAHL, PsychInfo, and Web of Science were systematically searched from inception to 2022. Two reviewers identified articles and removed duplicates. Next two reviewers independently screened titles and abstracts and then assessed full-texts articles for eligibility. Finally, all six reviewers examined full-text articles for eligibility and conducted the evidence synthesis.Eight randomized controlled trials were included. Studies were heterogeneous making direct comparisons challenging, but were grouped along three categories: aerobic, resistance, or resistance-aerobic exercises. One of three aerobic studies had positive quality-of-life outcomes. Fatigue improved in one aerobic and one combination resistance-aerobic study. Most resistance-aerobic studies and one aerobic study showed improved physical function. All resistance studies showed improvement in at least one outcome. Across all studies, ill health was the most common reason for participant dropout. The most commonly used assessment tools were: Functional Assessment of Cancer Therapy: Fatigue, European Organization for Research and Treatment of Cancer Quality-of-life Questionnaire Core 30, and accelerometer.Current randomized controlled trials regarding effects of exercise interventions on palliative outcomes for advanced cancer patients show great variability. While studies show promise, no generalizable conclusions can be made. Further research is needed.