神经保留根治前列腺切除术（NS RP）能够带来更好的功能结果。手术中神经血管结构相邻的冰冻切片检查（NeuroSAFE）显著增加了NS手术的频率，但对NeuroSAFE对于术后勃起功能（EF）和排尿控制的影响尚不清楚。本研究旨在描述应用NeuroSAFE技术进行RP的男性的EF和排尿控制结果。于2018年9月至2021年2月期间，共有1034名男性接受机器人辅助RP手术，通过验证问卷收集患者报告结果的数据。评估排尿控制使用国际失禁咨询问卷-泌尿失禁短表（ICIQ-UI SF）或扩展前列腺癌指数短表（EPIC-26），定义为每天使用0-1张护垫。评估勃起功能使用EPIC-26或国际勃起功能指数短表（IIEF-5），按照Vertosick的方法进行数据转换和分类。采用描述性统计学方法对肿瘤特征和排尿控制和EF结果进行评估和描述。在NeuroSAFE技术引入后接受RP的1034名男性中，分别有63％和60％的男性完成了关于排尿控制和勃起功能的术前和至少一次术后的问卷调查。接受单侧或双侧NS手术的男性中，93％和96％在1年和2年后报告了每天使用0-1张护垫；而接受非NS手术的男性的相应比例分别为86％和78％。总体而言，RP术后1年时92％的男性报告每天使用0-1张护垫，2年时为94％。NS组男性在RP术后拥有更高的良好或中等Vertosick评分比例比非NS组更高。总体而言，在1年和2年RP术后，44％的男性拥有良好或中等的Vertosick评分。NeuroSAFE技术引入后，接受RP的男性在术后1年时排尿控制率为92％，2年时为94％。相比非NS组，NS组男性拥有更高比例的中等或良好Vertosick评分和更高的RP术后排尿控制率。我们的研究表明，在去除前列腺的过程中引入NeuroSAFE技术之后，患者1年和2年的排尿控制率分别为92％和94％。术后1年和2年，约44％的男性勃起功能良好或中等。版权所有©2023作者。Elsevier B.V.保留所有权利。

Nerve-sparing (NS) radical prostatectomy (RP) results in better functional outcomes. Intraoperative neurovascular structure-adjacent frozen section examination (NeuroSAFE) significantly increases the frequency of NS surgery. The effect of NeuroSAFE on postoperative erectile function (EF) and continence is not yet clear.To describe EF and continence outcomes for men undergoing RP with the NeuroSAFE technique.Between September 2018 and February 2021, 1034 men underwent robot-assisted RP. Data for patient-reported outcomes were collected via validated questionnaires.NeuroSAFE technique for RP.Continence was assessed using the International Consultation on Incontinence Questionnaire-Urinary Incontinence Short Form (ICIQ-UI SF) or Expanded Prostate Cancer Index Composite short form (EPIC-26) and defined as use of 0-1 pads/d. EF was evaluated using EPIC-26 or the International Index of Erectile Function short form (IIEF-5), with data converted according to the Vertosick method and categorized. Descriptive statistics were used to asses and describe tumor characteristics and continence and EF outcomes.Of the 1034 men who underwent RP after introduction of the NeuroSAFE technique, 63% and 60% completed a preoperative and at least one postoperative questionnaire on continence and EF, respectively. Of the men who underwent unilateral or bilateral NS surgery, use of 0-1 pads/d was reported by 93% after 1 yr and 96% after 2 yr; the corresponding rates for men who underwent non-NS surgery were 86% and 78%. Overall, use of 0-1 pads/d was reported by 92% of the men at 1 yr and by 94% at 2 yr after RP. Men in the NS group had a good or intermediate Vertosick score after RP more often than the non-NS group. Overall, 44% of the men had a good or intermediate Vertosick score at 1 and 2 yr after RP.After introduction of the NeuroSAFE technique, the continence rate was 92% at 1 yr and 94% at 2 yr after RP. The NS group had a greater percentage of men with an intermediate or good Vertosick score and a higher continence rate after RP in comparison to the non-NS group.Our study shows that after introduction of the NeuroSAFE technique during removal of the prostate, the continence rate among patients was 92% at 1 year and 94% at 2 years after surgery. Some 44% of the men had a good or intermediate score for erectile function 1 and 2 years after surgery.Copyright © 2023 The Author(s). Published by Elsevier B.V. All rights reserved.