研究肿瘤/宿主因素（包括全身炎症反应）、表现方式和长/短期预后之间的关联，以接受TNM I-III结肠癌根治切除手术的患者为研究对象。紧急介入治疗结肠癌的患者与计划手术相比，即使经过TNM分期调整，长期预后仍较差。在紧急和计划手术中发现了肿瘤和宿主因素之间的一些差异，这些因素可能与不良预后有关。从2011年至2014年，在苏格兰西部接受TNM I-III结肠癌根治手术的患者被确定。确定与紧急介入治疗相关的肿瘤/宿主因素，并输入到后续的生存模型中，以确定与总体/癌特异性存活有关的独立因素（OS/CSS）。共鉴定了2705名患者。紧急介入治疗与计划手术相比，3年总体生存率和癌症特异性生存率较差（70％对86％和91％对75％）。 T分期、年龄、全身炎症等级（SIG）、贫血（均P＜0.001）、 N分期（P = 0.077）、肿瘤外静脉侵犯（P = 0.003）、BMI（P = 0.001）和ASA分级（P = 0.021）与紧急介入治疗有独立关联。其中：BMI（HR 0.82）、ASA（HR 1.45）、贫血（HR 1.29）、SIG（HR 1.11）、T分期（HR 1.57）、N分期（HR 1.80）和辅助化疗（HR 0.47）与OS有独立关联。CSS也观察到类似的结果。在接受结肠癌根治手术的患者中，紧急介入治疗不是独立与不良OS / CSS相关。相反，肿瘤和宿主因素的组合解释了观察到的差的预后。版权所有©2023 Wolters Kluwer Health，Inc.。保留所有权利。

To examine the association between tumour/host factors (including the systemic inflammatory response), mode of presentation and short/long-term outcomes in patients undergoing curative resectional surgery for TNM I-III colon cancer.Emergency presentations of colon cancer are associated with worse long-term outcomes than elective presentations despite adjustment for TNM Stage. A number of differences in tumour and host factors have been identified between elective and emergency presentations and it may be these factors that are associated with adverse outcomes.Patients undergoing curative surgery for TNM I-III colon cancer in the West of Scotland from 2011-2014 were identified. Tumour/host factors independently associated with emergency presentation were identified and entered into a subsequent survival model to determine those that were independently associated with overall/cancer-specific survival (OS/CSS).2705 patients were identified. Emergency presentation was associated with a worse 3-year overall and cancer specific survival compared to elective presentations (70% vs. 86% and 91% vs. 75%). T stage, age, Systemic Inflammatory Grade (SIG), anaemia (all P<0.001), N Stage (P=0.077), extramural venous invasion (P=0.003), BMI (P=0.001) and ASA classification (P=0.021) were independently associated with emergency presentation. Of these: BMI (HR 0.82), ASA (HR 1.45), anaemia (HR 1.29), SIG (HR 1.11), T Stage (HR 1.57), N Stage (HR 1.80) and adjuvant chemotherapy (HR 0.47) were independently associated with OS. Similar results were observed for CSS.Within patients undergoing curative surgery for colon cancer, emergency presentation was not independently associated with worse OS/CSS. Rather, a combination of tumour and host factors account for the worse outcomes observed.Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.