Sirtuin1（SIRT1）是一种保守的烟酰胺腺嘌呤二核苷酸（NAD +）依赖的组蛋白去乙酰化酶，在维持基因组稳定性，基因调控，细胞增殖和凋亡等一系列细胞事件中发挥关键作用。 P53是最为研究的肿瘤抑制因子之一，也是SIRT1非组蛋白靶点中第一个被鉴定出来的靶分子。 SIRT1以一种NAD +依赖性的方式对p53进行去乙酰化，并抑制其转录活性，从而对与组织稳态和各种病理状态相关的一系列途径产生作用。SIRT1-p53轴被认为在肿瘤发生中起着核心作用。虽然最初认为SIRT1是一种促肿瘤剂，但现有证据表明，SIRT1也可能是一种抑癌剂。这些看似矛盾的证据表明，SIRT1的功能可能由不同的细胞类型和细胞内定位模式决定。在本综述中，我们总结了与SIRT1和p53相互作用的最新证据，并讨论了这两种分子在与癌症相关的细胞事件中的相对作用。我们还提供了关于SIRT1-p53信号通路在肿瘤发生中的当前知识概述。鉴于SIRT1-p53途径的重要作用，针对这个轴的治疗策略可能提供有前途的治疗癌症的策略。版权所有©2023 Elsevier Inc.。

Sirtuin1 (SIRT1) is a conserved nicotinamide adenine dinucleotide (NAD+)-dependent histone deacetylase that plays key roles in a range of cellular events, including the maintenance of genome stability, gene regulation, cell proliferation, and apoptosis. P53 is one of the most studied tumor suppressors and the first identified non-histone target of SIRT1. SIRT1 deacetylates p53 in a NAD+-dependent manner and inhibits its transcriptional activity, thus exerting action on a series of pathways related to tissue homeostasis and various pathological states. The SIRT1-p53 axis is thought to play a central role in tumorigenesis. Although SIRT1 was initially identified as a tumor promoter, evidence now indicates that SIRT1 may also act as a tumor suppressor. This seemingly contradictory evidence indicates that the functionality of SIRT1 may be dictated by different cell types and intracellular localization patterns. In this review, we summarize recent evidence relating to the interactions between SIRT1 and p53 and discuss the relative roles of these two molecules with regards to cancer-associated cellular events. We also provide an overview of current knowledge of SIRT1-p53 signaling in tumorigenesis. Given the vital role of the SIRT1-p53 pathway, targeting this axis may provide promising strategies for the treatment of cancer.Copyright © 2023 Elsevier Inc. All rights reserved.