使用两种方法估计和讨论2017年西班牙17个地区35岁及以上人口的吸烟相关死亡率（SAM），采用流行率独立法（PIM）和流行率相关法（PDM）进行SAM的描述性分析。观察到的死亡率来自国家统计局；吸烟率来自3个全国性健康调查；肺癌死亡率来自癌症预防研究-II；相对风险来自5个美国队列。为每个地区整体、按性别和死因估计SAM和变化百分比。2017年，在应用PIM的情况下，烟草导致西班牙有56,203人死亡。使用PDM，死亡人数较低4.4%（95%CI：3.4-5.5）（53,825人）。除了4个地区外，PIM估计的整体SAM较高，最大变化百分比为18.6%。整体变化百分比对女性更高（15.7% 95%CI：12.6-19.0）和心血管疾病-糖尿病（13.8%；95%CI：11.5-16.2）。在国家层面上，两种方法估计的SAM数字相似。然而，在子国家层面上出现了估计差异。低吸烟率亚组和诱发期短于肺癌的死因的差异更大。版权所有©2023年作者。由爱思唯尔公司出版。保留所有权利。

To estimate and to discuss smoking-attributable mortality (SAM) for the 17 regions in Spain among population aged ≥35 years in 2017, using two methods.A descriptive analysis of SAM was conducted using two methods, the prevalence-independent method (PIM) and the prevalence-dependent method (PDM). Observed mortality was obtained from the National Institute of Statistics; smoking prevalence from 3 National Health Surveys; lung cancer mortality rates from the Cancer Prevention Study-II; and relative risks from 5 US cohorts. SAM and percentages of change were estimated for each region overall, by sex and cause of death.In 2017, tobacco caused 56,203 deaths in Spain applying the PIM. Using the PDM the number of deaths was a 4.4% (95%CI: 3.4-5.5) lower (53,825 deaths). Except in 4 regions, the PIM estimated a higher overall SAM and the maximum percentage of change was 18.6%. Overall percentages of change were higher for women (15.7% 95%CI: 12.6-19.0) and for cardiovascular diseases-diabetes mellitus (13.8%; 95%CI: 11.5-16.2).At the national level, both methods estimate similar figures of SAM. However, difference in estimates appears at the subnational level. Differences were higher in subgroups with lower smoking prevalence and for causes of death with periods of induction shorter than those for lung cancer.Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.