静止是细胞周期阻滞的一种状态，允许癌细胞逃避反增殖性癌症治疗。认为，静止的癌干细胞是导致胶质母细胞瘤抗治疗的主要原因，这是一种患者预后不佳的侵袭性脑癌。但是，胶质母细胞瘤细胞中静止状态的调节涉及许多与生俱来的和外在的机制，这些机制尚未完全理解。在本综述中，我们在胶质母细胞瘤背景下综合了有关静止状态调节机制的文献，并提出了一种以生态学视角为基础的干细胞样表型理论，将其锚定在生态位理论的当代概念上。从这个角度来看，细胞周期调节是多尺度和多维的，其中生态位维度扩展到肿瘤微环境中塑造细胞命运的外在变量。在这个概念框架内并通过生态位建模技术的支持，在寻找与低氧和机械信号相关的微环境变量，这些变量可调节增殖可塑性和肿瘤内免疫活性，这可能开辟了新的途径，以针对胶质母细胞瘤中出现的生物学弱点进行治疗，这些弱点无法仅从基因组学角度预测。版权所有©2023 Elsevier Ltd.

Quiescence is a state of cell cycle arrest, allowing cancer cells to evade anti-proliferative cancer therapies. Quiescent cancer stem cells are thought to be responsible for treatment resistance in glioblastoma, an aggressive brain cancer with poor patient outcomes. However, the regulation of quiescence in glioblastoma cells involves a myriad of intrinsic and extrinsic mechanisms that are not fully understood. In this review, we synthesise the literature on quiescence regulatory mechanisms in the context of glioblastoma and propose an ecological perspective to stemness-like phenotypes anchored to the contemporary concepts of niche theory. From this perspective, the cell cycle regulation is multiscale and multidimensional, where the niche dimensions extend to extrinsic variables in the tumour microenvironment that shape cell fate. Within this conceptual framework and powered by ecological niche modelling, the discovery of microenvironmental variables related to hypoxia and mechanosignalling that modulate proliferative plasticity and intratumor immune activity may open new avenues for therapeutic targeting of emerging biological vulnerabilities in glioblastoma that cannot be anticipated from genomics alone.Copyright © 2023. Published by Elsevier Ltd.