Rubus chingii的叶子中存在的噶马酸型二萜苷glycoside中的Rubochingosides A - J。
Rubochingosides A - J, labdane-type diterpene glycosides from leaves of Rubus chingii.
发表日期：2023 Apr 08
作者：
Jianxiong Wang, Xiaowu Xiao, Nian Zhou, Minmin Zhao, Shuqin Lang, Qi Ren, Dong Wang, Huizheng Fu
来源：
PHYTOCHEMISTRY
摘要：
从刺悬崖悬铃木(Rubus chingii Hu)的叶子中分离出10个新颖的拉丹型三萜类化合物，命名为rubochingoside A - J（1-10）。它们的结构通过光谱学和化学方法得到澄清。对所有分离得到的化合物进行了抗5种人类肿瘤细胞系（Bel-7402、Caski、BGC-823、A2780和HCT-116）细胞毒性测试。其中，化合物4和8对Bel-7402和A2780细胞表现出细胞毒性，IC50值分别为10.43±0.51和29.03±2.94μM；化合物8对Bel-7402和HCT-116细胞表现出细胞毒性，IC50值分别为17.78±1.54和26.23±6.14μM。本文版权所有©2023 Elsevier Ltd.
Ten previously undescribed labdane-type triterpenoids, rubochingosides A - J (1-10), were isolated from the leaves of Rubus chingii Hu. Their structures were elucidated by spectroscopic and chemical methods. The cytotoxicity of all isolated compounds was tested against five human tumor cell lines (Bel-7402, Caski, BGC-823, A2780, and HCT-116). Among them, compounds 4 and 8 showed cytotoxic activities against Bel-7402 and A2780 cells with IC50 values of 10.43 ± 0.51 and 29.03 ± 2.94 μM, respectively; Compound 8 exhibited cytotoxic activities against Bel-7402 and HCT-116 cells with IC50 values of 17.78 ± 1.54 and 26.23 ± 6.14 μM, respectively.Copyright © 2023 Elsevier Ltd. All rights reserved.