ChemoNETosis：肿瘤治疗抵抗的一条道路。
ChemoNETosis: A road to tumor therapeutic resistance.
发表日期：2023 Apr 10
作者：
Phei Er Saw, Jianing Chen, Erwei Song
来源：
CANCER CELL
摘要：
中性粒细胞外泌物网（NET）通过捕获微生物限制感染，最近被证明可导致肿瘤转移。在《癌细胞》杂志上，Mousset等人说明化疗引起的炎症通过促进恶性肿瘤中的NET溶解产生化疗耐药性，强调了通过靶向癌症治疗中的炎症NET提供治疗机会的重要性。Copyright © 2023 Elsevier Inc. All rights reserved.
Neutrophil extracellular traps (NETs) limit infection by trapping microorganisms and have recently been shown to induce tumor metastasis. In this issue of Cancer Cell, Mousset et al. illustrate how chemotherapy-induced inflammation confers chemoresistance by facilitating NETosis in malignant tumors, highlighting a therapeutic opportunity to target inflammatory NETs in cancer treatment.Copyright © 2023 Elsevier Inc. All rights reserved.