Ewing肉瘤治疗：基因治疗方法。
Ewing sarcoma treatment: a gene therapy approach.
发表日期：2023 Apr 10
作者：
Sergey Tsibulnikov, Daria Fayzullina, Irina Karlina, Brett A Schroeder, Olga Karpova, Peter Timashev, Ilya Ulasov
来源：
CANCER GENE THERAPY
摘要：
Ewing肉瘤（ES）是一种侵略性恶性肿瘤，其特征是非随机染色体易位产生融合基因。融合基因和融合蛋白产物是基因治疗的有前途的靶点。治疗方法和策略根据感兴趣的靶分子（核苷酸、蛋白质）而异。我们提供了一份关于基因治疗活性分子和基因治疗递送方法的广泛文献综述，这两者对于成功治疗都是必要的。© 2023年。作者（们），在Springer Nature America，Inc.的独家许可下发布。
Ewing sarcoma (ES) is an aggressive malignant tumor, characterized by non-random chromosomal translocations that produce fusion genes. Fusion genes and fusion protein products are promising targets for gene therapy. Therapeutic approaches and strategies vary based on target molecules (nucleotides, proteins) of interest. We present an extensive literature review of active molecules for gene therapy and methods of gene therapy delivery, both of which are necessary for successful treatment.© 2023. The Author(s), under exclusive licence to Springer Nature America, Inc.