在减轻宫颈癌负担时，宫颈涂片检查中经历的疼痛是一个重要的差距。这项研究旨在调查在宫颈涂片检查的最后添加一个无痛步骤是否有助于妇女记忆减少疼痛。我们在一个宫颈癌筛查中心对年龄在30岁至70岁之间的妇女进行了一项随机对照试验。在改良版宫颈涂片检查中，在宫颈涂片检查的最后添加了一个无痛步骤。结果包括宫颈涂片筛查后的记忆疼痛、即时疼痛和1年内接受进一步宫颈涂片检查的意愿。在意图治疗分析的266名受试者中，改良版宫颈涂片检查组（n = 133）在1到5数字评分尺度（平均[标准差]，1.50 [0.77] vs 2.02 [1.12]; P <0.001）和0到10视觉模拟评分尺度（2.12 [1.79] vs 3.12 [2.23]; P <0.001）上的5分钟记忆疼痛较传统宫颈涂片检查组低。在探索性亚组分析中，改良版宫颈涂片检查和减少5分钟记忆疼痛之间的关联不受预测疼痛、人口统计学或社会经济特征的影响，但在绝经后妇女中更为明显。一致地，改良版宫颈涂片检查减轻了疼痛的1年记忆，并增强了接受进一步定期宫颈涂片检查的意愿等级。总之，在宫颈涂片筛查中添加一个无痛步骤可以减少现场和长期回忆的疼痛，并增强接受后续定期宫颈涂片检查的意愿。改良版宫颈涂片检查有助于宫颈癌筛查参与。版权所有©2023年国际疼痛研究协会。

The pain experienced during Pap tests is a crucial gap in reducing cervical cancer burden. This study sought to investigate whether adding a nonpainful step at the end of Pap tests helps women recall less pain. We conducted a randomized controlled trial on women aged 30 to 70 years at a cervical cancer screening center. A nonpainful step was added at the end of Pap test in the modified Pap group. The outcomes included recalled pain after Pap smear screening, real-time pain, and 1-year willingness to receive further Pap tests. Among 266 subjects in the intention-to-treat analysis, the modified Pap group (n = 133) experienced lower 5-minute recalled pain than the traditional Pap group on a 1 to 5 numeric scale (mean [SD], 1.50 [0.77] vs 2.02 [1.12]; P < 0.001) and a 0 to 10 visual analog scale (2.12 [1.79] vs 3.12 [2.23]; P < 0.001). In exploratory subgroup analyses, the association between the modified Pap test and reduced 5-minute recalled pain was not affected by predicted pain, demographic, or socioeconomic characteristics, but it was more apparent in postmenopausal women. Consistently, the modified Pap test attenuated 1-year recalled pain on both pain scales. Furthermore, the modified Pap test increased 1-year willingness grade to receive further Pap tests (adjusted β [SE], 2.11 [0.27]; P < 0.001). In conclusion, adding a nonpainful step at the end of Pap smear screening reduces on-site and long-term recalled pain and strengthens willingness to undergo subsequent Pap tests regularly. The modified Pap test contributes to cervical cancer screening participation.Copyright © 2023 International Association for the Study of Pain.