虽然在肺免疫学方面已经取得了显著进展，但还有很多工作需要做，以全面解释肺部协调免疫反应。 SARS-CoV-2大流行只凸显出当前宿主 - 病原体相互作用模型的不足，并加强了当前和未来一代免疫学家解决复杂生物问题的必要性。作为这一努力的一部分，第64届Thomas L. Petty Aspen Lung Conference的主题是“弥合肺部先天免疫和适应性免疫之间的鸿沟”，并展示了来自知名免疫学家的令人兴奋的工作。本报告总结了2022年阿斯彭肺病会议的会议内容，该会议旨在讨论先天和适应性免疫在疾病发病机制中的作用，评估先天和适应性免疫反应之间的接口，评估适应性免疫在自身免疫性和自身免疫性肺疾病中的作用，讨论从免疫学癌症治疗和方法中学到的经验教训，并定义利用免疫系统预防和治疗肺部疾病的新范式。

Although significant strides in the understanding of pulmonary immunology have been made, much work remains to be done to comprehensively explain coordinated immune responses in the lung. The SARS-CoV-2 pandemic only served to highlight the inadequacy of current models of host-pathogen interactions and reinforced the need for current and future generations of immunologists to unravel complex biological questions. As part of that effort, the 64th Annual Thomas L. Petty Aspen Lung Conference was themed "Bridging the Gap Between Innate and Adaptive Immunity in the Lung" and featured exciting work from renowned immunologists. This report summarizes the proceedings of the 2022 Aspen Lung Conference, which was convened to discuss the roles played by innate and adaptive immunity in disease pathogenesis, evaluate the interface between the innate and adaptive immune responses, assess the role of adaptive immunity in the development of autoimmunity and autoimmune lung disease, discuss lessons learned from immunologic cancer treatments and approaches, and define new paradigms to harness the immune system to prevent and treat lung diseases.