硒纳米粒子 (SeNPs) 是一种独特的纳米级元素硒，在生物医学领域中最近得到广泛应用。研究表明，SeNPs 的性质可以通过不同的制备方法来改变。此外，SeNPs 由于其优秀的生物和适应性物理特性，在医疗应用中具有各种不同的治疗效果。同时，SeNPs 还可用作各种治疗物质的载体介质，从而发挥药物的充分治疗效果。在本篇综述中，回顾了不同物质制备的 SeNPs 的生物活性特性差异；讨论了 SeNPs 在癌症、炎症、神经退行性疾病、糖尿病、生殖疾病、心血管疾病和其他疾病的治疗效果和机制；并进一步强调了 SeNPs 的开发的重要性。版权©2023年。由Elsevier B.V.出版。

Selenium nanoparticles (SeNPs) are a unique type of nano-sized elemental selenium that have recently found wide application in biomedicine. It has been shown that the properties of SeNPs can be varied by different fabrication methods. Moreover, SeNPs have various therapeutic effects in medical applications due to their excellent biological and adaptable physical properties. At the same time, SeNPs can be used as a carrier medium for various therapeutic substances, which can bring out the full curative effects of the drugs. In this review, the differences in bioactivity properties of SeNPs prepared from different substances were reviewed; the therapeutic effects and mechanisms of SeNPs in cancer, inflammation, neurodegenerative diseases, diabetes, reproductive diseases, cardiovascular diseases, and other diseases were discussed; and the importance of the development of SeNPs was further emphasized.Copyright © 2023. Published by Elsevier B.V.