芹菜素作为一种炎症反应调节剂：更新概述及治疗潜力。
Galangin as an inflammatory response modulator: An updated overview and therapeutic potential.
发表日期：2023 Apr 10
作者：
Riya Thapa, Obaid Afzal, Abdulmalik Saleh Alfawaz Altamimi, Ahsas Goyal, Waleed Hassan Almalki, Sami I Alzarea, Imran Kazmi, Vikash Jakhmola, Sachin Kumar Singh, Kamal Dua, Ritu Gilhotra, Gaurav Gupta
来源：
CHEMICO-BIOLOGICAL INTERACTIONS
摘要：
许多慢性疾病如癌症、糖尿病、类风湿性关节炎、心血管疾病和胃肠疾病均具有炎症基础病因。在炎症的细胞和动物模型中，黄酮类化合物被用来展示其强大的抗炎活性。黄酮类化合物增强了抗炎细胞因子转化生长因子和白细胞介素-10（IL-10）的合成，同时减少了前列腺素IL-6、肿瘤坏死因子-α（TNF-α）和前列腺素E2（PGE2）、IL-1的合成。天然黄酮类化合物之一的莪术素（GAL）具有控制凋亡和炎症的强大能力。研究发现GAL能够抑制细胞外信号调节激酶（ERK）和核因子-kappa轻链增强激活B细胞（NF-κB）p65的磷酸化，从而具有抗炎作用。GAL已用于治疗关节炎、炎性支气管炎、中风和认知功能障碍。本文目的在于展示GAL的抗炎特性及其在治疗各种慢性疾病（包括心脏病、脑病、皮肤病、肺病、肝病和炎症性肠病）中的保护作用。版权所有©2023 Elsevier B.V.
Numerous chronic diseases, such as cancer, diabetes, rheumatoid arthritis, cardiovascular disease, and gastrointestinal disorders, all have an inflammation-based etiology. In cellular and animal models of inflammation, flavonols were used to show potent anti-inflammatory activity. The flavonols enhanced the synthesis of the anti-inflammatory cytokines transforming growth factor and interleukin-10 (IL-10) and reduced the synthesis of the prostaglandins IL-6, tumor necrosis factor-alpha (TNF-α), and prostaglandin E2 (PGE2), IL-1. Galangin (GAL), a natural flavonol, has a strong ability to control apoptosis and inflammation. GAL was discovered to suppress extracellular signal-regulated kinase (ERK) and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB)p65 phosphorylation, which results in anti-inflammatory actions. Arthritis, inflammatory bronchitis, stroke, and cognitive dysfunction have all been treated with GAL. The current review aimed to demonstrate the anti-inflammatory properties of GAL and their protective effects in treating various chronic illnesses, including those of the heart, brain, skin, lungs, liver, and inflammatory bowel diseases.Copyright © 2023 Elsevier B.V. All rights reserved.