Nemorosone是一个双环多异戊二烯基酰基苯酚衍生物，最初是从Clusia spp中分离出来的，它可以通过采用不同的合成策略进行化学合成。自从其发现以来，它引起了生物学和化学角度的极大关注。在本文中，我们试图审查有关nemorosone的各种化学和生物学主题，重点关注其抗增殖活性。为此，从包括Google Scholar、PubMed、Scopus和ISI Web of Knowledge在内的不同科学数据库收集了相关数据。该天然化合物已经显示出对多种恶性肿瘤的活性，如白血病、人类结直肠、胰腺和乳腺癌，因为它调节多种分子途径。Nemorosone具有细胞静止和细胞毒性活性，还似乎能诱导细胞凋亡和铁死亡。此外，它对属于Leishmania属的革兰氏阳性细菌和寄生虫具有抗菌能力。其有前途的抗增殖临床前效应值得进一步关注，以用于抗癌和抗寄生虫药物的开发和转化至临床应用。版权所有 © 2023 Elsevier Ltd.

Nemorosone is a bicyclic polyprenylated acylphloroglucinol derivative originally isolated from Clusia spp. and it can be obtained through chemical synthesis employing different synthetic strategies. Since its discovery, it has attracted great attention both from a biological and chemical viewpoint. In the present article, we attempted to review various chemical and biological topics around nemorosone, with an emphasis on its antiproliferative activities. For this purpose, relevant data was collected from different scientific databases including Google Scholar, PubMed, Scopus and ISI Web of Knowledge. This natural compound has shown activity against several types of malignancies such as leukemia, human colorectal, pancreatic, and breast cancer because it modulates multiple molecular pathways. Nemorosone has both cytostatic and cytotoxic activity and it also seems to induce apoptosis and ferroptosis. Additionally, it has antimicrobial capabilities against Gram-positive bacteria and parasites belonging to genus Leishmania. Its promising antiproliferative pre-clinical effects deserve further attention for anticancer and anti-parasitic drug development and translation to the clinic.Copyright © 2023. Published by Elsevier Ltd.