宏自噬/自噬是一种保守的分解代谢途径，对于维持细胞稳态和在压力条件下促进细胞生存至关重要。自噬失调与多种人类疾病有关，例如癌症、神经退行性疾病和代谢障碍。因此，必须在多个水平上精确调节此途径，涉及表观遗传、转录、后转录、翻译和后翻译机制，以防止不适当的自噬活动。在本文中，我们重点关注自噬在转录水平上的调节，总结了控制酵母和哺乳动物细胞自噬基因表达的转录因子。由于某些自噬转录因子的表达和/或亚细胞定位在某些疾病中发生改变，因此我们还讨论了自噬转录调节的变化如何与人类病理生理学相关。©2023作者，通过ADMC Associazione Differenziamento e Morte Cellulare独家许可。

Macroautophagy/autophagy is a conserved catabolic pathway that is vital for maintaining cell homeostasis and promoting cell survival under stressful conditions. Dysregulation of autophagy is associated with a variety of human diseases, such as cancer, neurodegenerative diseases, and metabolic disorders. Therefore, this pathway must be precisely regulated at multiple levels, involving epigenetic, transcriptional, post-transcriptional, translational, and post-translational mechanisms, to prevent inappropriate autophagy activity. In this review, we focus on autophagy regulation at the transcriptional level, summarizing the transcription factors that control autophagy gene expression in both yeast and mammalian cells. Because the expression and/or subcellular localization of some autophagy transcription factors are altered in certain diseases, we also discuss how changes in transcriptional regulation of autophagy are associated with human pathophysiologies.© 2023. The Author(s), under exclusive licence to ADMC Associazione Differenziamento e Morte Cellulare.