口腔癌是全球最常见的癌症之一，其发病率存在区域差异。本研究使用1980年至2019年获得的癌症登记数据库，通过平均年百分比变化率（AAPC）和年龄-时期-队列模型分析口腔癌的发病特征。使用Spearman的相关性分析口腔癌的年龄标准化发病率（ASR）与相关风险因素之间的关系。结果显示，1980-1984年至2015-2019年间，男性口腔癌ASR从每10万人口的4.19增加至27.19，AAPC为5.1％（95％CI = 3.9-6.3，p值<0.001），女性口腔癌ASR从每10万人口的1.16增加至2.8，AAPC为3.1％（95％CI = 2.6-3.6，p值<0.001）。年龄-时期-队列模型表明，男性患病率比率呈上升后下降的趋势，峰值出现在1975年队列，比率为6.80。口腔癌的发病趋势与香烟和酒精消费以及槟榔制品的生产变化相关，其相关系数分别为0.952、0.979和0.963（所有p值<0.001）。我们强烈建议避免这些风险因素以预防口腔癌。

Oral cancer (OC) is one of the most common cancers worldwide, and its incidence has regional differences. In this study, the cancer registry database obtained from 1980 to 2019 was used to analyze the characteristic of incidence of OC by average annual percentage change (AAPC) and an age-period-cohort model. Spearman's correlation was used to analyze the relationship between the age-standard incidence rates (ASR) of OC and related risk factors. Our results showed that the ASR of OC increased from 4.19 to 27.19 per 100,000 population with an AAPC of 5.1% (95% CI = 3.9-6.3, p value < 0.001) in men and from 1.16 to 2.8 per 100,000 population with an AAPC of 3.1% (95% CI = 2.6-3.6, p value < 0.001) in women between 1980-1984 and 2015-2019. The age-period-cohort model reported a trend of rising then declining for the rate ratio in men, with peaks occurring in the 1975 cohort, with a rate ratio of 6.80. The trend of incidence of oral cancer was related to changes in the consumption of cigarettes and alcohol and production of betel quid, with r values of 0.952, 0.979 and 0.963, respectively (all p values < 0.001). We strongly suggest avoiding these risk factors in order to prevent OC.