研究动态
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MR Vascular Fingerprinting与Hybrid Gradient-Spin Echo Dynamic Susceptibility Contrast MRI用于表征胶质瘤微血管。

MR Vascular Fingerprinting with Hybrid Gradient-Spin Echo Dynamic Susceptibility Contrast MRI for Characterization of Microvasculature in Gliomas.

发表日期:2023 Apr 06
作者: Krishnapriya Venugopal, Fatemeh Arzanforoosh, Daniëlle van Dorth, Marion Smits, Matthias J P van Osch, Juan A Hernandez-Tamames, Esther A H Warnert, Dirk H J Poot
来源: Cancers

摘要:

肿瘤微血管的表征在肿瘤评估和研究治疗反应中非常重要。基于动态敏感性对比(DSC)的磁共振成像(MRI)可以获得血管生物标记物以实现这一目的。我们提出采用混合回波平面成像(HEPI)在对比剂(CA)第一次通过时进行磁共振血管指纹(MRVF)制备。该方法在胶质瘤患者中进行了评估,我们同时估计了血管半径和相对脑血容量。这些参数还与先前引入的血管大小成像(VSI)技术估计的相应值进行了比较,两种方法的结果都一致。MRVF还在参数估计中表现出了噪声鲁棒性。基于DSC-HEPI的MRVF提供了一种在短时间内对胶质瘤微血管进行表征的方法,可以通过多种方式进一步改进,以增加我们对肿瘤生理学的理解。
Characterization of tumor microvasculature is important in tumor assessment and studying treatment response. This is possible by acquiring vascular biomarkers with magnetic resonance imaging (MRI) based on dynamic susceptibility contrast (DSC). We propose magnetic resonance vascular fingerprinting (MRVF) for hybrid echo planar imaging (HEPI) acquired during the first passage of the contrast agent (CA). The proposed approach was evaluated in patients with gliomas, and we simultaneously estimated vessel radius and relative cerebral blood volume. These parameters were also compared to the respective values estimated using the previously introduced vessel size imaging (VSI) technique. The results of both methods were found to be consistent. MRVF was also found to be robust to noise in the estimation of the parameters. DSC-HEPI-based MRVF provides characterization of microvasculature in gliomas with a short acquisition time and can be further improved in several ways to increase our understanding of tumor physiology.