脑胶质母细胞瘤研究的一个领域是瘤细胞代谢，并检测肿瘤和健康脑组织代谢之间的差异。我们在这里审查了脂肪酸代谢中的差异，特别关注由脂肪酸合酶、延长酶和去饱和酶合成的饱和脂肪酸（SFA）、单不饱和脂肪酸（MUFA）和多不饱和脂肪酸（PUFA）的生物合成。我们还描述了个别脂肪酸在脑胶质母细胞瘤发生中的重要性，以及甘油磷脂和三酰甘油合成在这一过程中的重要性。具体而言，我们展示了各种甘油-3-磷酸酰转移酶（GPAT）的同工酶、1-酰基甘油-3-磷酸O-酰基转移酶（AGPAT）、脂肪酰磷酸酯酶以及参与磷脂酰胆碱（PC）、磷脂酰乙醇胺（PE）、磷脂酰丝氨酸（PS）、磷脂酰肌醇（PI）和心磷脂（CL）合成的酶的重要性和功能。此外，本文还强调了二酰甘油O-酰基转移酶（DGAT）在三酰甘油生物合成中的参与。由于知识上的重大空缺，我们利用GEPIA数据库展示了个别酶在脑胶质母细胞瘤发生中的重要性。最后，我们还描述了脂滴在脑胶质母细胞瘤中的重要性，以及脂肪酸合成特别是二十二碳六烯酸（DHA）对细胞膜流动性和表皮生长因子受体（EGFR）信号传导的影响。

One area of glioblastoma research is the metabolism of tumor cells and detecting differences between tumor and healthy brain tissue metabolism. Here, we review differences in fatty acid metabolism, with a particular focus on the biosynthesis of saturated fatty acids (SFA), monounsaturated fatty acids (MUFA), and polyunsaturated fatty acids (PUFA) by fatty acid synthase (FASN), elongases, and desaturases. We also describe the significance of individual fatty acids in glioblastoma tumorigenesis, as well as the importance of glycerophospholipid and triacylglycerol synthesis in this process. Specifically, we show the significance and function of various isoforms of glycerol-3-phosphate acyltransferases (GPAT), 1-acylglycerol-3-phosphate O-acyltransferases (AGPAT), lipins, as well as enzymes involved in the synthesis of phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidylserine (PS), phosphatidylinositol (PI), and cardiolipin (CL). This review also highlights the involvement of diacylglycerol O-acyltransferase (DGAT) in triacylglycerol biosynthesis. Due to significant gaps in knowledge, the GEPIA database was utilized to demonstrate the significance of individual enzymes in glioblastoma tumorigenesis. Finally, we also describe the significance of lipid droplets in glioblastoma and the impact of fatty acid synthesis, particularly docosahexaenoic acid (DHA), on cell membrane fluidity and signal transduction from the epidermal growth factor receptor (EGFR).