食管肿瘤微环境中上皮细胞和成纤维细胞共同进化的见解。
Insights into the co-evolution of epithelial cells and fibroblasts in the esophageal tumor microenvironment.
发表日期：2023 Apr 06
作者：
Hagar Lavon, Ruth Scherz-Shouval
来源：
CANCER CELL
摘要：
癌相关成纤维细胞（CAFs）被癌细胞吸引并重构成为促癌形成的细胞。这种交流的分子机制在食管癌中完全未知。陈等人发现，食管前癌上皮细胞通过下调ANXA1-FRP2信号重构正常居住的成纤维细胞成为CAFs。版权所有©2023 Elsevier Inc.。保留所有权利。
Cancer-associated fibroblasts (CAFs) are recruited and rewired by cancer cells to become protumorigenic. The molecular mechanisms underlying this crosstalk in esophageal cancer are completely unknown. Chen et al. discover that premalignant epithelial cells of the esophagus rewire normal resident fibroblasts into CAFs through the downregulation of ANXA1-FRP2 signaling.Copyright © 2023 Elsevier Inc. All rights reserved.