脑缺血性卒中和胶质瘤是全球病人死亡的两个主要原因。尽管生理变异，10人中有1人患有脑缺血性卒中后会发展成脑癌，尤其是胶质瘤。此外，胶质瘤的治疗也已被证明会增加脑缺血的风险。根据传统文献，癌症患者中中风的发生率比普通人群更高。令人难以置信的是，这些事件共享多个途径，但共同发生的精确机制仍未知晓。转录因子（TF），基因表达程序的主要组成部分，最终确定细胞和体内稳态的命运。脑缺血性卒中和胶质瘤均表现出大量TF异常表达，这些TF与两种疾病的病理生理学和进展密切相关。尽管人们对于TF如何调节脑缺血性卒中和胶质瘤疾病基因表达产生强烈兴趣，但TF的精确基因组结合位置以及如何最终与转录调节相关仍然未知。因此，在本文中强调了继续努力了解TF介导的基因调控的重要性，以及脑缺血性卒中和胶质瘤中的一些共同事件。 版权所有 © 2023 Elsevier Ltd.

Cerebral ischemic stroke and glioma are the two leading causes of patient mortality globally. Despite physiological variations, 1 in 10 people who have an ischemic stroke go on to develop brain cancer, most notably gliomas. In addition, glioma treatments have also been shown to increase the risk of ischemic strokes. Stroke occurs more frequently in cancer patients than in the general population, according to traditional literature. Unbelievably, these events share multiple pathways, but the precise mechanism underlying their co-occurrence remains unknown. Transcription factors (TFs), the main components of gene expression programmes, finally determine the fate of cells and homeostasis. Both ischemic stroke and glioma exhibit aberrant expression of a large number of TFs, which are strongly linked to the pathophysiology and progression of both diseases. The precise genomic binding locations of TFs and how TF binding ultimately relates to transcriptional regulation remain elusive despite a strong interest in understanding how TFs regulate gene expression in both stroke and glioma. As a result, the importance of continuing efforts to understand TF-mediated gene regulation is highlighted in this review, along with some of the primary shared events in stroke and glioma.Copyright © 2023 Elsevier Ltd. All rights reserved.