研究动态
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天然高脂肪基黄酮的植物化学和药理学。

Phytochemistry and pharmacology of natural prenylated flavonoids.

发表日期:2023 Apr 14
作者: Hua-Wei Lv, Qiao-Liang Wang, Meng Luo, Meng-Di Zhu, Hui-Min Liang, Wen-Jing Li, Hai Cai, Zhong-Bo Zhou, Hong Wang, Sheng-Qiang Tong, Xing-Nuo Li
来源: ARCHIVES OF PHARMACAL RESEARCH

摘要:

假麝香类类黄酮化合物是一种特殊的类黄酮衍生物,在类黄酮的母核上具有一个或多个假麝香基团。假麝香侧链的存在丰富了类黄酮的结构多样性,增加了它们的生物活性和生物利用度。假麝香类类黄酮表现出广泛的生物活性,如抗癌、抗炎、神经保护、抗糖尿病、抗肥胖、心脏保护作用和抗成骨细胞生成活性。近年来,随着不断挖掘假麝香类类黄酮的药用价值,已发现许多具有显著活性的化合物,引起了药理学家的广泛关注。本文综述了近年来对天然活性假麝香类类黄酮的研究进展,促进了对其药用价值的新发现。©2023.韩国药学学会。
Prenylated flavonoids are a special kind of flavonoid derivative possessing one or more prenyl groups in the parent nucleus of the flavonoid. The presence of the prenyl side chain enriched the structural diversity of flavonoids and increased their bioactivity and bioavailability. Prenylated flavonoids show a wide range of biological activities, such as anti-cancer, anti-inflammatory, neuroprotective, anti-diabetic, anti-obesity, cardioprotective effects, and anti-osteoclastogenic activities. In recent years, many compounds with significant activity have been discovered with the continuous excavation of the medicinal value of prenylated flavonoids, and have attracted the extensive attention of pharmacologists. This review summarizes recent progress on research into natural active prenylated flavonoids to promote new discoveries of their medicinal value.© 2023. The Pharmaceutical Society of Korea.