本研究比较了成年儿童癌症幸存者（CCS）的全面心理社会结果与普通基于人口的参考组，并确定了社会人口统计和医疗风险因素。来自荷兰儿童癌症幸存者研究（DCCSS）-LATER队列（1963年至2001年诊断）第2部分（年龄≥18岁，诊断<18岁，诊断后≥5年）的CCS完成了罗森伯格自尊量表、医院焦虑和抑郁量表、烦躁度量表、自评剧创伤后应激障碍量表和短表格36项（健康相关的生活质量）。使用方差分析和 logistic 回归分析将CCS的得分与参考组进行比较，并控制年龄和性别（p < .05）。通过回归分析评估了更糟心理社会结果的风险因素（p < .05）。共有1797名CCS，平均年龄为35.4岁，49.0％为女性，所有人均在诊断后≥15年，参加了研究。3％的人因儿童癌症而报告创伤后应激障碍，36.6％的人经历了临床痛苦。CCS在自尊和焦虑方面与参考组没有差异，但抑郁较轻（d = -.25），并且在所有与健康相关的生活质量尺度上得分较低，除了身体疼痛之外（.01 ≤ d ≥ -.36）。女性、教育水平较低、无情侣关系和失业与几乎所有心理社会结果均呈负相关。除中枢神经系统肿瘤诊断外，很少有医学特征与心理社会结果相关。CCS在心理健康方面表现出弹性，但健康相关的生活质量略差于参考组。社会人口统计特征和中枢神经系统肿瘤与大多数心理社会结果有关，但其他医学因素没有明显模式。未来研究应考虑其他因素，如应对、社会支持和身体后遗症，以解释CCS的心理社会功能。© 2023 The Authors. Cancer published by Wiley Periodicals LLC on behalf of American Cancer Society.

This study compares a comprehensive range of psychosocial outcomes of adult childhood cancer survivors (CCS) to general population-based references and identifies sociodemographic and medical risk factors.CCS from the Dutch Childhood Cancer Survivor Study (DCCSS)-LATER cohort (diagnosed 1963-2001) part 2 (attained age ≥18 years, diagnosed <18 years, ≥5 years since diagnosis) completed the Rosenberg Self-Esteem Scale, Hospital Anxiety and Depression Scale, Distress Thermometer, Self-Rating Scale for Post-Traumatic Stress Disorder, and the Short Form-36 (Health Related Quality of Life). CCS' scores were compared with references using analysis of variances and logistic regression analysis, controlling for age and sex (p < .05). Risk factors for worse psychosocial outcomes were assessed with regression analyses (p < .05).CCS, N = 1797, mean age 35.4 years, 49.0% female, all ≥15 years since diagnosis, participated. Three percent reported posttraumatic stress disorder because of childhood cancer and 36.6% experienced clinical distress. CCS did not differ from references on self-esteem and anxiety but were less depressed (d = -.25), and scored poorer on all health-related quality of life scales, except for bodily pain (.01 ≤ d  ≥  -.36). Female sex, lower educational attainment, not being in a relationship, and being unemployed were negatively associated with almost all psychosocial outcomes. Except for a central nervous system tumor diagnosis, few medical characteristics were associated with psychosocial outcomes.CCS appear resilient regarding mental health but have slightly poorer health-related quality of life than references. Sociodemographic characteristics and central nervous system tumors were related to most psychosocial outcomes, but no clear pattern was observed for other medical factors. Future studies should address additional factors in explaining CCS' psychosocial functioning, such as coping, social support, and physical late effects.© 2023 The Authors. Cancer published by Wiley Periodicals LLC on behalf of American Cancer Society.