在癌症中外细胞囊泡的作用。
The role of extracellular vesicles in cancer.
发表日期：2023 Apr 13
作者：
Raghu Kalluri, Kathleen M McAndrews
来源：
CELL
摘要：
细胞间通讯是癌症进展和转移的关键特征。所有细胞，包括癌细胞，产生细胞外囊泡（EVs）。最近的研究已经确定了EVs作为细胞间通讯的关键介质，通过包装和传递生物活性成分来影响癌细胞和肿瘤微环境细胞的生物学和功能。在这里，我们回顾了EVs在癌症进展和转移，癌症生物标志物和癌症治疗药物开发中的功能贡献的最新研究进展。版权所有©2023 Elsevier Inc.。保留所有权利。
Intercellular communication is a key feature of cancer progression and metastasis. Extracellular vesicles (EVs) are generated by all cells, including cancer cells, and recent studies have identified EVs as key mediators of cell-cell communication via packaging and transfer of bioactive constituents to impact the biology and function of cancer cells and cells of the tumor microenvironment. Here, we review recent advances in understanding the functional contribution of EVs to cancer progression and metastasis, as cancer biomarkers, and the development of cancer therapeutics.Copyright © 2023 Elsevier Inc. All rights reserved.