免疫检查点治疗 - 当前的观点和未来的方向。
Immune checkpoint therapy-current perspectives and future directions.
发表日期：2023 Apr 13
作者：
Padmanee Sharma, Sangeeta Goswami, Deblina Raychaudhuri, Bilal A Siddiqui, Pratishtha Singh, Ashwat Nagarajan, Jielin Liu, Sumit K Subudhi, Candice Poon, Kristal L Gant, Shelley M Herbrich, Swetha Anandhan, Shajedul Islam, Moran Amit, Gayathri Anandappa, James P Allison
来源：
CELL
摘要：
免疫检查点疗法（ICT）已经显著改变了癌症患者的临床结果，并提供了持久的临床效益，包括一部分患者的治愈。不同肿瘤类型的反应率不同，需要预测性生物标志物来优化患者选择，以最大限度地提高疗效并减少毒副作用，从而促使解开免疫和非免疫因素调节ICT的反应的努力。本文重点介绍了抗肿瘤免疫的生物学基础，阐述了ICT目前的挑战，概述了指导随后的临床试验和ICT联合应用的策略。版权所有 © 2023 Elsevier Inc.。
Immune checkpoint therapy (ICT) has dramatically altered clinical outcomes for cancer patients and conferred durable clinical benefits, including cure in a subset of patients. Varying response rates across tumor types and the need for predictive biomarkers to optimize patient selection to maximize efficacy and minimize toxicities prompted efforts to unravel immune and non-immune factors regulating the responses to ICT. This review highlights the biology of anti-tumor immunity underlying response and resistance to ICT, discusses efforts to address the current challenges with ICT, and outlines strategies to guide the development of subsequent clinical trials and combinatorial efforts with ICT.Copyright © 2023 Elsevier Inc. All rights reserved.