癌基因组学的核心任务是全面绘制癌症驱动事件的分子基础，提供个体化治疗策略。该领域主要关注癌细胞，成功揭示了许多重要癌症类型的驱动因子。随着癌症免疫逃逸成为关键癌症标志的出现，该范式已被提升到了整体肿瘤生态系统，阐明了不同的细胞组成及其功能状态。我们强调了癌症基因组学的里程碑，描绘了该领域的进化路径，并讨论了在完善对肿瘤生态系统的理解以及推进治疗策略方面的未来方向。版权所有 © 2023 Elsevier Inc.保留所有权利。

A core mission of cancer genomics is to comprehensively chart molecular underpinnings of cancer-driving events and to provide personalized therapeutic strategies. Primarily focused on cancer cells, cancer genomics studies have successfully uncovered many drivers for major cancer types. Since the emergence of cancer immune evasion as a critical cancer hallmark, the paradigm has been elevated to the holistic tumor ecosystem, with distinct cellular components and their functional states elucidated. We highlight the milestones of cancer genomics, depict the evolving path of the field, and discuss future directions in completing the understanding of the tumor ecosystem and in advancing therapeutic strategies.Copyright © 2023 Elsevier Inc. All rights reserved.