恶人无法休息：肿瘤细胞衰老重塑免疫微环境。
No rest for the wicked: Tumor cell senescence reshapes the immune microenvironment.
发表日期：2023 Mar 29
作者：
Ann Hanna, Justin M Balko
来源：
CANCER CELL
摘要：
Senescence induces key phenotypic changes that can modulate immune responses. 四篇近期发表于《癌症研究》、《自然》和《自然癌症》的文章强调了，衰老的正常细胞或化疗处理过的细胞会表达抗原呈递机制，呈递抗原，与T细胞和树突状细胞相互作用，从而强有力地激活免疫系统，促进抗肿瘤免疫力。 版权所有© 2023 Elsevier Inc.。保留所有权利。
Senescence induces key phenotypic changes that can modulate immune responses. Four recent publications in Cancer Discovery, Nature, and Nature Cancer highlight how senescent cells (aged normal or chemotherapy-treated cells) express antigen presentation machinery, present antigens, and interact with T cells and dendritic cells to robustly activate the immune system and promote anti-tumor immunity.Copyright © 2023 Elsevier Inc. All rights reserved.