葡萄糖转运蛋白家族(GLUT)包含十四个成员。其负责维持葡萄糖稳态并将葡萄糖从细胞外向细胞质进行进一步级联催化的运输。GLUT蛋白是由溶质载体家族2(SLC2)基因编码的，是膜转运体的主要促进者超家族的成员。此外，不同的GLUTs也具有其不同的转运动力学和分布，因此每个GLUT成员都有其独特性和在人体生理中发挥重要作用的重要性。糖尿病领域的许多研究证据表明，GLUT4在质膜和细胞内囊泡(GLUT4存储泡)之间移动，并且PI3K/Akt途径以胰岛素依赖方式或由于肌肉收缩而通过AMPK途径调节这种活动。此外，一些发表的结果还指出，GLUT4介导胰岛素依赖性的葡萄糖摄取。因此，GLUT4的功能障碍可以引起胰岛素抵抗、多种慢性疾病的代谢重编程、炎症和癌症。除GLUT4与胰岛素反应之外，最近研究还提到了可能与GLUT4启动子区域结合以调节下游信号的潜在上游转录因子。综合所有证据，我们得出结论，GLUT4显示出有价值的未知功能，并在癌症临床意义上具有重要意义，值得我们深入讨论和基于结构设计化合物以实现治疗效果。因此，我们打算撰写一篇最新的评论手稿，包括最近和最关键的研究结果，阐明GLUT4在癌变中扮演重要角色的原因和如何，可能对该领域产生广泛的兴趣和影响。版权所有©2023 Elsevier B.V.

The glucose transporter family (GLUT) consists of fourteen members. It is responsible for glucose homeostasis and glucose transport from the extracellular space to the cell cytoplasm to further cascade catalysis. GLUT proteins are encoded by the solute carrier family 2 (SLC2) genes and are members of the major facilitator superfamily of membrane transporters. Moreover, different GLUTs also have their transporter kinetics and distribution, so each GLUT member has its uniqueness and importance to play essential roles in human physiology. Evidence from many studies in the field of diabetes showed that GLUT4 travels between the plasma membrane and intracellular vesicles (GLUT4-storage vesicles, GSVs) and that the PI3K/Akt pathway regulates this activity in an insulin-dependent manner or by the AMPK pathway in response to muscle contraction. Moreover, some published results also pointed out that GLUT4 mediates insulin-dependent glucose uptake. Thus, dysfunction of GLUT4 can induce insulin resistance, metabolic reprogramming in diverse chronic diseases, inflammation, and cancer. In addition to the relationship between GLUT4 and insulin response, recent studies also referred to the potential upstream transcription factors that can bind to the promoter region of GLUT4 to regulating downstream signals. Combined all of the evidence, we conclude that GLUT4 has shown valuable unknown functions and is of clinical significance in cancers, which deserves our in-depth discussion and design compounds by structure basis to achieve therapeutic effects. Thus, we intend to write up a most updated review manuscript to include the most recent and critical research findings elucidating how and why GLUT4 plays an essential role in carcinogenesis, which may have broad interests and impacts on this field.Copyright © 2023. Published by Elsevier B.V.